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Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor.
Mov Disord. 2010 Jul 30; 25(10):1350-6.MD

Abstract

To evaluate the posterior subthalamic area (PSA) as a target for deep brain stimulation (DBS) in the treatment of essential tremor (ET). The ventral intermediate nucleus of the thalamus is the traditional target for DBS in the treatment of ET. Recent studies have presented beneficial effects of DBS in the PSA in the treatment of tremor. Twenty-one patients with ET were included in this study. All patients were evaluated before and 1 year after surgery, on and off stimulation, using the essential tremor rating scale (ETRS). A marked microlesional effect was noticed in 83%, in some cases obviating the need for electrical stimulation for many months. The total ETRS was reduced from 46.2 at baseline to 18.7 (60%). Item 5/6 (tremor of the upper extremity) was improved from 6.2 to 0.3 (95%), and items 11 to 14 (hand function) from 9.7 to 1.3 (87%) concerning the contralateral hand. Activities of daily living were improved by 66%. No severe complication occurred. Eight patients presented a postoperative mild dysphasia that regressed within days to weeks. DBS in the PSA resulted in a marked reduction of tremor.

Authors+Show Affiliations

Department of Neurosurgery, University Hospital of Northern Sweden, Umeå, Sweden. patric.blomstedt@neuro.umu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

20544817

Citation

Blomstedt, Patric, et al. "Deep Brain Stimulation in the Posterior Subthalamic Area in the Treatment of Essential Tremor." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25, no. 10, 2010, pp. 1350-6.
Blomstedt P, Sandvik U, Tisch S. Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor. Mov Disord. 2010;25(10):1350-6.
Blomstedt, P., Sandvik, U., & Tisch, S. (2010). Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor. Movement Disorders : Official Journal of the Movement Disorder Society, 25(10), 1350-6. https://doi.org/10.1002/mds.22758
Blomstedt P, Sandvik U, Tisch S. Deep Brain Stimulation in the Posterior Subthalamic Area in the Treatment of Essential Tremor. Mov Disord. 2010 Jul 30;25(10):1350-6. PubMed PMID: 20544817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor. AU - Blomstedt,Patric, AU - Sandvik,Ulrika, AU - Tisch,Stephen, PY - 2010/6/15/entrez PY - 2010/6/15/pubmed PY - 2010/12/14/medline SP - 1350 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 IS - 10 N2 - To evaluate the posterior subthalamic area (PSA) as a target for deep brain stimulation (DBS) in the treatment of essential tremor (ET). The ventral intermediate nucleus of the thalamus is the traditional target for DBS in the treatment of ET. Recent studies have presented beneficial effects of DBS in the PSA in the treatment of tremor. Twenty-one patients with ET were included in this study. All patients were evaluated before and 1 year after surgery, on and off stimulation, using the essential tremor rating scale (ETRS). A marked microlesional effect was noticed in 83%, in some cases obviating the need for electrical stimulation for many months. The total ETRS was reduced from 46.2 at baseline to 18.7 (60%). Item 5/6 (tremor of the upper extremity) was improved from 6.2 to 0.3 (95%), and items 11 to 14 (hand function) from 9.7 to 1.3 (87%) concerning the contralateral hand. Activities of daily living were improved by 66%. No severe complication occurred. Eight patients presented a postoperative mild dysphasia that regressed within days to weeks. DBS in the PSA resulted in a marked reduction of tremor. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20544817/Deep_brain_stimulation_in_the_posterior_subthalamic_area_in_the_treatment_of_essential_tremor_ L2 - https://doi.org/10.1002/mds.22758 DB - PRIME DP - Unbound Medicine ER -