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Mitochondrial dysfunction in neurodegenerative diseases and cancer.
Environ Mol Mutagen. 2010 Jun; 51(5):391-405.EM

Abstract

Mitochondria are important integrators of cellular function and therefore affect the homeostatic balance of the cell. Besides their important role in producing adenosine triphosphate through oxidative phosphorylation, mitochondria are involved in the control of cytosolic calcium concentration, metabolism of key cellular intermediates, and Fe/S cluster biogenesis and contributed to programmed cell death. Mitochondria are also one of the major cellular producers of reactive oxygen species (ROS). Several human pathologies, including neurodegenerative diseases and cancer, are associated with mitochondrial dysfunction and increased ROS damage. This article reviews how dysfunctional mitochondria contribute to Alzheimer's disease, Parkinson's disease, Huntington's disease, and several human cancers.

Authors+Show Affiliations

Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20544881

Citation

de Moura, Michelle Barbi, et al. "Mitochondrial Dysfunction in Neurodegenerative Diseases and Cancer." Environmental and Molecular Mutagenesis, vol. 51, no. 5, 2010, pp. 391-405.
de Moura MB, dos Santos LS, Van Houten B. Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environ Mol Mutagen. 2010;51(5):391-405.
de Moura, M. B., dos Santos, L. S., & Van Houten, B. (2010). Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environmental and Molecular Mutagenesis, 51(5), 391-405. https://doi.org/10.1002/em.20575
de Moura MB, dos Santos LS, Van Houten B. Mitochondrial Dysfunction in Neurodegenerative Diseases and Cancer. Environ Mol Mutagen. 2010;51(5):391-405. PubMed PMID: 20544881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial dysfunction in neurodegenerative diseases and cancer. AU - de Moura,Michelle Barbi, AU - dos Santos,Lucas Santana, AU - Van Houten,Bennett, PY - 2010/6/15/entrez PY - 2010/6/15/pubmed PY - 2010/7/7/medline SP - 391 EP - 405 JF - Environmental and molecular mutagenesis JO - Environ. Mol. Mutagen. VL - 51 IS - 5 N2 - Mitochondria are important integrators of cellular function and therefore affect the homeostatic balance of the cell. Besides their important role in producing adenosine triphosphate through oxidative phosphorylation, mitochondria are involved in the control of cytosolic calcium concentration, metabolism of key cellular intermediates, and Fe/S cluster biogenesis and contributed to programmed cell death. Mitochondria are also one of the major cellular producers of reactive oxygen species (ROS). Several human pathologies, including neurodegenerative diseases and cancer, are associated with mitochondrial dysfunction and increased ROS damage. This article reviews how dysfunctional mitochondria contribute to Alzheimer's disease, Parkinson's disease, Huntington's disease, and several human cancers. SN - 1098-2280 UR - https://www.unboundmedicine.com/medline/citation/20544881/Mitochondrial_dysfunction_in_neurodegenerative_diseases_and_cancer_ L2 - https://doi.org/10.1002/em.20575 DB - PRIME DP - Unbound Medicine ER -