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Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden.
Epidemiol Infect. 2011 Mar; 139(3):361-71.EI

Abstract

Hepatitis E infections in humans are usually acquired in endemic countries in Asia or Africa. In Sweden 17 cases infected in Europe, between 1993 and 2009, were identified. All had clinical hepatitis E with unknown source of infection. Hepatitis E virus (HEV) was identified in faecal samples from 63 piglets in 12 pig farms in Sweden. HEV was also identified in blood from 13 out of 159 investigated Swedish wild boars from nine counties. Partial HEV genomes from humans, pigs and wild boars were sequenced and compared by phylogeny. The results showed close relatedness between HEV strains from piglets from the same farm and from wild boars from the same county. HEV strains from humans showed relatedness with strains from pigs and wild boars from the same county. This study showed that HEV strains form geographical clusters in the phylogenetic tree. The methods used in this study may thus be used for tracing the origin of an infecting strain. Furthermore, this study indicated that there are endemic sources of human HEV infections in Sweden.

Authors+Show Affiliations

Department of Virology, Immunobiology and Parasitology, Statens Veterinärmedicinska Anstalt & Department of Biomedicine and Veterinary Public Health, The Swedish University of Agricultural Sciences, Uppsala, Sweden. frederik.widen@sva.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20546635

Citation

Widén, F, et al. "Molecular Epidemiology of Hepatitis E Virus in Humans, Pigs and Wild Boars in Sweden." Epidemiology and Infection, vol. 139, no. 3, 2011, pp. 361-71.
Widén F, Sundqvist L, Matyi-Toth A, et al. Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden. Epidemiol Infect. 2011;139(3):361-71.
Widén, F., Sundqvist, L., Matyi-Toth, A., Metreveli, G., Belák, S., Hallgren, G., & Norder, H. (2011). Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden. Epidemiology and Infection, 139(3), 361-71. https://doi.org/10.1017/S0950268810001342
Widén F, et al. Molecular Epidemiology of Hepatitis E Virus in Humans, Pigs and Wild Boars in Sweden. Epidemiol Infect. 2011;139(3):361-71. PubMed PMID: 20546635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden. AU - Widén,F, AU - Sundqvist,L, AU - Matyi-Toth,A, AU - Metreveli,G, AU - Belák,S, AU - Hallgren,G, AU - Norder,H, Y1 - 2010/06/14/ PY - 2010/6/16/entrez PY - 2010/6/16/pubmed PY - 2011/3/10/medline SP - 361 EP - 71 JF - Epidemiology and infection JO - Epidemiol Infect VL - 139 IS - 3 N2 - Hepatitis E infections in humans are usually acquired in endemic countries in Asia or Africa. In Sweden 17 cases infected in Europe, between 1993 and 2009, were identified. All had clinical hepatitis E with unknown source of infection. Hepatitis E virus (HEV) was identified in faecal samples from 63 piglets in 12 pig farms in Sweden. HEV was also identified in blood from 13 out of 159 investigated Swedish wild boars from nine counties. Partial HEV genomes from humans, pigs and wild boars were sequenced and compared by phylogeny. The results showed close relatedness between HEV strains from piglets from the same farm and from wild boars from the same county. HEV strains from humans showed relatedness with strains from pigs and wild boars from the same county. This study showed that HEV strains form geographical clusters in the phylogenetic tree. The methods used in this study may thus be used for tracing the origin of an infecting strain. Furthermore, this study indicated that there are endemic sources of human HEV infections in Sweden. SN - 1469-4409 UR - https://www.unboundmedicine.com/medline/citation/20546635/Molecular_epidemiology_of_hepatitis_E_virus_in_humans_pigs_and_wild_boars_in_Sweden_ L2 - https://www.cambridge.org/core/product/identifier/S0950268810001342/type/journal_article DB - PRIME DP - Unbound Medicine ER -