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Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism.
Gastroenterology 2010; 139(3):779-87, 787.e1G

Abstract

BACKGROUND & AIMS

Patients with inflammatory bowel disease (IBD) are at increased risk of a first venous thromboembolism (VTE), yet their risk of recurrent VTE is unknown. We performed a cohort study to determine the risk for recurrent VTE among patients with IBD compared with subjects without IBD.

METHODS

We assessed 2811 patients with IBD for a history of VTE, recruited from outpatient clinics at 14 referral centers (June 2006-December 2008). Patients with VTE before a diagnosis of IBD or those not confirmed to have VTE, cancer, or a VTE other than deep vein thrombosis or pulmonary embolism, were excluded. Recurrence rates were compared with 1255 prospectively followed patients without IBD that had a first unprovoked VTE (not triggered by trauma, surgery, or pregnancy). The primary end point was symptomatic, objectively confirmed, recurrent VTE after discontinuation of anticoagulation therapy after a first VTE.

RESULTS

Overall, of 116 IBD patients who had a history of first VTE, 86 were unprovoked. The probability of recurrence 5 years after discontinuation of anticoagulation therapy was higher among patients with IBD than patients without IBD (33.4%; 95% confidence interval [CI]: 21.8-45.0 vs 21.7%; 95% CI: 18.8-24.6; P = .01). After adjustment for potential confounders, IBD was an independent risk factor of recurrence (hazard ratio = 2.5; 95% CI: 1.4-4.2; P = .001).

CONCLUSIONS

Patients with IBD are at an increased risk of recurrent VTE compared to patients without IBD.

Authors+Show Affiliations

Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. gottfried.novacek@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20546736

Citation

Novacek, Gottfried, et al. "Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism." Gastroenterology, vol. 139, no. 3, 2010, pp. 779-87, 787.e1.
Novacek G, Weltermann A, Sobala A, et al. Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism. Gastroenterology. 2010;139(3):779-87, 787.e1.
Novacek, G., Weltermann, A., Sobala, A., Tilg, H., Petritsch, W., Reinisch, W., ... Eichinger, S. (2010). Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism. Gastroenterology, 139(3), pp. 779-87, 787.e1. doi:10.1053/j.gastro.2010.05.026.
Novacek G, et al. Inflammatory Bowel Disease Is a Risk Factor for Recurrent Venous Thromboembolism. Gastroenterology. 2010;139(3):779-87, 787.e1. PubMed PMID: 20546736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory bowel disease is a risk factor for recurrent venous thromboembolism. AU - Novacek,Gottfried, AU - Weltermann,Ansgar, AU - Sobala,Anna, AU - Tilg,Herbert, AU - Petritsch,Wolfgang, AU - Reinisch,Walter, AU - Mayer,Andreas, AU - Haas,Thomas, AU - Kaser,Arthur, AU - Feichtenschlager,Thomas, AU - Fuchssteiner,Harry, AU - Knoflach,Peter, AU - Vogelsang,Harald, AU - Miehsler,Wolfgang, AU - Platzer,Reingard, AU - Tillinger,Wolfgang, AU - Jaritz,Bernhard, AU - Schmid,Alfons, AU - Blaha,Benedikt, AU - Dejaco,Clemens, AU - Eichinger,Sabine, Y1 - 2010/06/12/ PY - 2010/01/22/received PY - 2010/04/11/revised PY - 2010/05/13/accepted PY - 2010/6/16/entrez PY - 2010/6/16/pubmed PY - 2010/9/21/medline SP - 779-87, 787.e1 JF - Gastroenterology JO - Gastroenterology VL - 139 IS - 3 N2 - BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) are at increased risk of a first venous thromboembolism (VTE), yet their risk of recurrent VTE is unknown. We performed a cohort study to determine the risk for recurrent VTE among patients with IBD compared with subjects without IBD. METHODS: We assessed 2811 patients with IBD for a history of VTE, recruited from outpatient clinics at 14 referral centers (June 2006-December 2008). Patients with VTE before a diagnosis of IBD or those not confirmed to have VTE, cancer, or a VTE other than deep vein thrombosis or pulmonary embolism, were excluded. Recurrence rates were compared with 1255 prospectively followed patients without IBD that had a first unprovoked VTE (not triggered by trauma, surgery, or pregnancy). The primary end point was symptomatic, objectively confirmed, recurrent VTE after discontinuation of anticoagulation therapy after a first VTE. RESULTS: Overall, of 116 IBD patients who had a history of first VTE, 86 were unprovoked. The probability of recurrence 5 years after discontinuation of anticoagulation therapy was higher among patients with IBD than patients without IBD (33.4%; 95% confidence interval [CI]: 21.8-45.0 vs 21.7%; 95% CI: 18.8-24.6; P = .01). After adjustment for potential confounders, IBD was an independent risk factor of recurrence (hazard ratio = 2.5; 95% CI: 1.4-4.2; P = .001). CONCLUSIONS: Patients with IBD are at an increased risk of recurrent VTE compared to patients without IBD. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/20546736/Inflammatory_bowel_disease_is_a_risk_factor_for_recurrent_venous_thromboembolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(10)00754-7 DB - PRIME DP - Unbound Medicine ER -