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Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.
Fitoterapia. 2010 Oct; 81(7):855-8.F

Abstract

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sulaiman MR
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Perimal EK
No affiliation info available
Akhtar MN
No affiliation info available
Mohamad AS
No affiliation info available
Khalid MH
No affiliation info available
Tasrip NA
No affiliation info available
Mokhtar F
No affiliation info available
Zakaria ZA
No affiliation info available
Lajis NH
No affiliation info available
Israf DA
No affiliation info available

MeSH

AnimalsAnti-Inflammatory AgentsCarrageenanDisease Models, AnimalEdemaGossypiumGranulomaInflammationMaleMiceMice, Inbred ICRPhytotherapyPlant ExtractsRhizomeSesquiterpenesZingiberaceae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20546845

Citation

Sulaiman, M R., et al. "Anti-inflammatory Effect of Zerumbone On Acute and Chronic Inflammation Models in Mice." Fitoterapia, vol. 81, no. 7, 2010, pp. 855-8.
Sulaiman MR, Perimal EK, Akhtar MN, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010;81(7):855-8.
Sulaiman, M. R., Perimal, E. K., Akhtar, M. N., Mohamad, A. S., Khalid, M. H., Tasrip, N. A., Mokhtar, F., Zakaria, Z. A., Lajis, N. H., & Israf, D. A. (2010). Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81(7), 855-8. https://doi.org/10.1016/j.fitote.2010.05.009
Sulaiman MR, et al. Anti-inflammatory Effect of Zerumbone On Acute and Chronic Inflammation Models in Mice. Fitoterapia. 2010;81(7):855-8. PubMed PMID: 20546845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. AU - Sulaiman,M R, AU - Perimal,E K, AU - Akhtar,M N, AU - Mohamad,A S, AU - Khalid,M H, AU - Tasrip,N A, AU - Mokhtar,F, AU - Zakaria,Z A, AU - Lajis,N H, AU - Israf,D A, Y1 - 2010/05/28/ PY - 2010/03/25/received PY - 2010/05/12/revised PY - 2010/05/14/accepted PY - 2010/6/16/entrez PY - 2010/6/16/pubmed PY - 2011/4/30/medline SP - 855 EP - 8 JF - Fitoterapia JO - Fitoterapia VL - 81 IS - 7 N2 - The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/20546845/Anti_inflammatory_effect_of_zerumbone_on_acute_and_chronic_inflammation_models_in_mice_ DB - PRIME DP - Unbound Medicine ER -