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Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models.
J Ethnopharmacol. 2010 Jul 20; 130(2):334-9.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied.

AIM OF THE STUDY

This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides.

MATERIALS AND METHODS

The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined.

RESULTS

In the ethanol-induced ulcer model, it was observed that the treatment with Achyrocline satureoides extract significantly reduced the lesion index by 75.1+/-8.6, 85.0+/-9.2, 86.6+/-7.4 and 75.5+/-5.3 for the groups treated with 100, 250 and 500 mg/kg of extract of inflorescences of Achyrocline satureoides and the positive control (omeprazole 30 mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5+/-7.1, 62.5+/-6.1, 63.6+/-5.5 and 96.2+/-3.6 for the groups treated with 100, 250 and 500 mg/kg of extract and the positive control (cimetidine 100 mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H(+)]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of Achyrocline satureoides (100, 250 and 500 mg/kg), significantly increased mucus production (p<0.01), when compared with the groups treated with indomethacin (100 mg/kg), cimetidine (100 mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study.

CONCLUSIONS

The results of the present study show that hydroalcoholic extract of Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer.

Authors+Show Affiliations

Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí-UNIVALI, Itajaí, Santa Catarina, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20546870

Citation

Santin, José Roberto, et al. "Antiulcer Effects of Achyrocline Satureoides (Lam.) DC (Asteraceae) (Marcela), a Folk Medicine Plant, in Different Experimental Models." Journal of Ethnopharmacology, vol. 130, no. 2, 2010, pp. 334-9.
Santin JR, Lemos M, Klein Júnior LC, et al. Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. J Ethnopharmacol. 2010;130(2):334-9.
Santin, J. R., Lemos, M., Klein Júnior, L. C., Niero, R., & de Andrade, S. F. (2010). Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. Journal of Ethnopharmacology, 130(2), 334-9. https://doi.org/10.1016/j.jep.2010.05.014
Santin JR, et al. Antiulcer Effects of Achyrocline Satureoides (Lam.) DC (Asteraceae) (Marcela), a Folk Medicine Plant, in Different Experimental Models. J Ethnopharmacol. 2010 Jul 20;130(2):334-9. PubMed PMID: 20546870.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models. AU - Santin,José Roberto, AU - Lemos,Marivane, AU - Klein Júnior,Luiz Carlos, AU - Niero,Rivaldo, AU - de Andrade,Sérgio Faloni, Y1 - 2010/05/28/ PY - 2010/03/03/received PY - 2010/05/04/revised PY - 2010/05/09/accepted PY - 2010/6/16/entrez PY - 2010/6/16/pubmed PY - 2010/11/5/medline SP - 334 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 130 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Achyrocline satureoides is a medium-sized South American indigenous herb, commonly known as "Marcela" or "Macela". The infusion obtained from inflorescences of this plant is widely used in Brazilian folk medicine as an antispasmodic, anti-inflammatory, hypoglycemic, and hypocholesterolemic, mainly to treat gastrointestinal disorders such as gastric ulcers and dyspepsia. However, the antiulcer properties of this species have not yet been fully studied. AIM OF THE STUDY: This study was conducted to evaluate and contribute to validating the antiulcer activity of hydroalcoholic extract of inflorescences of Achyrocline satureoides. MATERIALS AND METHODS: The antiulcer assays were performed using the ethanol-induced ulcer, and nonsteroidal anti-inflammatory drug (NSAID)-induced ulcer protocols. Gastric secretion parameters were also evaluated (volume, pH and total acidity) by the pylorus ligated model, and the mucus in the gastric content was determined. RESULTS: In the ethanol-induced ulcer model, it was observed that the treatment with Achyrocline satureoides extract significantly reduced the lesion index by 75.1+/-8.6, 85.0+/-9.2, 86.6+/-7.4 and 75.5+/-5.3 for the groups treated with 100, 250 and 500 mg/kg of extract of inflorescences of Achyrocline satureoides and the positive control (omeprazole 30 mg/kg), respectively. Significant inhibition was also observed in the lesion index in the indomethacin-induced ulcer model, with decreases of 62.5+/-7.1, 62.5+/-6.1, 63.6+/-5.5 and 96.2+/-3.6 for the groups treated with 100, 250 and 500 mg/kg of extract and the positive control (cimetidine 100 mg/kg), respectively. The parameters of gastric secretion (pH, volume, [H(+)]) showed no alteration in the different doses of the treatment. On the other hand the treatment with the hydroalcoholic extract of Achyrocline satureoides (100, 250 and 500 mg/kg), significantly increased mucus production (p<0.01), when compared with the groups treated with indomethacin (100 mg/kg), cimetidine (100 mg/kg) and negative control (vehicle). No signs of toxicity was observed in the acute toxicity study. CONCLUSIONS: The results of the present study show that hydroalcoholic extract of Achyrocline satureoides displays antiulcer activity, as demonstrated by the significant inhibition of the formation of ulcers induced using different models. However, this activity appears not be related to the antisecretor mechanisms. Moreover, this work suggests that preparations obtained from Achyrocline satureoides could be used for the development of new phytotherapic drugs for the treatment of gastric ulcer. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/20546870/Antiulcer_effects_of_Achyrocline_satureoides__Lam___DC__Asteraceae___Marcela__a_folk_medicine_plant_in_different_experimental_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00320-X DB - PRIME DP - Unbound Medicine ER -