Citation
Shin, Ji-Sun, et al. "Sulfuretin Isolated From Heartwood of Rhus Verniciflua Inhibits LPS-induced Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines Expression Via the Down-regulation of NF-kappaB in RAW 264.7 Murine Macrophage Cells." International Immunopharmacology, vol. 10, no. 8, 2010, pp. 943-50.
Shin JS, Park YM, Choi JH, et al. Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. Int Immunopharmacol. 2010;10(8):943-50.
Shin, J. S., Park, Y. M., Choi, J. H., Park, H. J., Shin, M. C., Lee, Y. S., & Lee, K. T. (2010). Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. International Immunopharmacology, 10(8), 943-50. https://doi.org/10.1016/j.intimp.2010.05.007
Shin JS, et al. Sulfuretin Isolated From Heartwood of Rhus Verniciflua Inhibits LPS-induced Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines Expression Via the Down-regulation of NF-kappaB in RAW 264.7 Murine Macrophage Cells. Int Immunopharmacol. 2010;10(8):943-50. PubMed PMID: 20546946.
TY - JOUR
T1 - Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells.
AU - Shin,Ji-Sun,
AU - Park,Young Mi,
AU - Choi,Jung-Hye,
AU - Park,Hee-Juhn,
AU - Shin,Min Cheol,
AU - Lee,Yong Sup,
AU - Lee,Kyung-Tae,
Y1 - 2010/05/28/
PY - 2010/02/11/received
PY - 2010/05/08/revised
PY - 2010/05/16/accepted
PY - 2010/6/16/entrez
PY - 2010/6/16/pubmed
PY - 2011/3/4/medline
SP - 943
EP - 50
JF - International immunopharmacology
JO - Int Immunopharmacol
VL - 10
IS - 8
N2 - It has been reported that Rhusverniciflua exhibits anti-inflammatory, anti-oxidant and anti-cancer activities. However, little is known about biological activity of sulfuretin, a flavonoid isolated from R.verniciflua. In the present study, we investigated the anti-inflammatory effect and the underlying molecular mechanisms of sulfuretin in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Sulfuretin dose-dependently reduced the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) induced by LPS. Consistent with these findings, sulfuretin significantly suppressed the LPS-induced expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-alpha, and IL-1 beta. In addition, sulfuretin attenuated LPS-induced DNA binding and the transcriptional activities of nuclear factor-kappa B (NF-kappaB), which was accompanied by a parallel reduction of degradation and phosphorylation of inhibitory kappa B-alpha (I kappaB-alpha) and consequently by decreased nuclear translocation of p65 subunit of NF-kappaB. Furthermore, pretreatment with sulfuretin significantly inhibited the LPS-stimulated activation of I kappaB kinase beta (IKK beta). Taken together, these results suggest that the anti-inflammatory effect of sulfuretin in LPS-treated RAW 264.7 macrophages is associated with the suppression of NF-kappaB transcriptional activity via the inhibitory regulation of IKKbeta phosphorylation.
SN - 1878-1705
UR - https://www.unboundmedicine.com/medline/citation/20546946/Sulfuretin_isolated_from_heartwood_of_Rhus_verniciflua_inhibits_LPS_induced_inducible_nitric_oxide_synthase_cyclooxygenase_2_and_pro_inflammatory_cytokines_expression_via_the_down_regulation_of_NF_kappaB_in_RAW_264_7_murine_macrophage_cells_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(10)00166-9
DB - PRIME
DP - Unbound Medicine
ER -
