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Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes.
Early Hum Dev 2010; 86(5):305-10EH

Abstract

BACKGROUND

Maternal perinatal mental health has been shown to be associated with adverse consequences for the mother and the child. However, studies considering the effect of DSM-IV anxiety disorders beyond maternal self-perceived distress during pregnancy and its timing are lacking.

AIMS

To examine the role of maternal anxiety disorders with an onset before birth and self-perceived distress during pregnancy for unfavourable maternal, obstetric, neonatal and childhood outcomes.

STUDY DESIGN

DSM-IV mental disorders and self-perceived distress of 992 mothers as well as obstetric, neonatal and childhood outcomes of their offspring were assessed in a cohort sampled from the community using the Munich-Composite International Diagnostic Interview. Logistic regression analyses revealed associations (odds ratios) between maternal anxiety disorders and self-perceived distress during pregnancy with maternal depression after birth and a range of obstetric, neonatal and childhood psychopathological outcomes.

RESULTS

Lifetime maternal anxiety disorders were related to offspring anxiety disorders, but not to offspring externalizing disorders. Analyses focussing on maternal DSM-IV anxiety disorders before birth yielded associations with incident depression after birth. In addition, self-perceived distress during pregnancy was associated with maternal depression after birth, preterm delivery, caesarean section, separation anxiety disorder, ADHD, and conduct disorder in offspring.

CONCLUSION

Findings confirm the transmission of anxiety disorders from mother to offspring. Apart from maternal anxiety, self-perceived distress during pregnancy also emerged as a putative risk factor for adverse outcomes. The finding that maternal anxiety disorders before birth yielded less consistent associations, suggests that self-perceived distress during pregnancy might be seen as a putative moderator/mediator in the familial transmission of anxiety.

Authors+Show Affiliations

Institute of Clinical Psychology and Psychotherapy, Technische Universitaet, Dresden, Germany. martini@psychologie.tu-dresden.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20547016

Citation

Martini, Julia, et al. "Anxiety Disorders Before Birth and Self-perceived Distress During Pregnancy: Associations With Maternal Depression and Obstetric, Neonatal and Early Childhood Outcomes." Early Human Development, vol. 86, no. 5, 2010, pp. 305-10.
Martini J, Knappe S, Beesdo-Baum K, et al. Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Hum Dev. 2010;86(5):305-10.
Martini, J., Knappe, S., Beesdo-Baum, K., Lieb, R., & Wittchen, H. U. (2010). Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. Early Human Development, 86(5), pp. 305-10. doi:10.1016/j.earlhumdev.2010.04.004.
Martini J, et al. Anxiety Disorders Before Birth and Self-perceived Distress During Pregnancy: Associations With Maternal Depression and Obstetric, Neonatal and Early Childhood Outcomes. Early Hum Dev. 2010;86(5):305-10. PubMed PMID: 20547016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiety disorders before birth and self-perceived distress during pregnancy: associations with maternal depression and obstetric, neonatal and early childhood outcomes. AU - Martini,Julia, AU - Knappe,Susanne, AU - Beesdo-Baum,Katja, AU - Lieb,Roselind, AU - Wittchen,Hans-Ulrich, Y1 - 2010/05/23/ PY - 2009/07/08/received PY - 2010/01/27/revised PY - 2010/04/20/accepted PY - 2010/6/16/entrez PY - 2010/6/16/pubmed PY - 2010/9/30/medline SP - 305 EP - 10 JF - Early human development JO - Early Hum. Dev. VL - 86 IS - 5 N2 - BACKGROUND: Maternal perinatal mental health has been shown to be associated with adverse consequences for the mother and the child. However, studies considering the effect of DSM-IV anxiety disorders beyond maternal self-perceived distress during pregnancy and its timing are lacking. AIMS: To examine the role of maternal anxiety disorders with an onset before birth and self-perceived distress during pregnancy for unfavourable maternal, obstetric, neonatal and childhood outcomes. STUDY DESIGN: DSM-IV mental disorders and self-perceived distress of 992 mothers as well as obstetric, neonatal and childhood outcomes of their offspring were assessed in a cohort sampled from the community using the Munich-Composite International Diagnostic Interview. Logistic regression analyses revealed associations (odds ratios) between maternal anxiety disorders and self-perceived distress during pregnancy with maternal depression after birth and a range of obstetric, neonatal and childhood psychopathological outcomes. RESULTS: Lifetime maternal anxiety disorders were related to offspring anxiety disorders, but not to offspring externalizing disorders. Analyses focussing on maternal DSM-IV anxiety disorders before birth yielded associations with incident depression after birth. In addition, self-perceived distress during pregnancy was associated with maternal depression after birth, preterm delivery, caesarean section, separation anxiety disorder, ADHD, and conduct disorder in offspring. CONCLUSION: Findings confirm the transmission of anxiety disorders from mother to offspring. Apart from maternal anxiety, self-perceived distress during pregnancy also emerged as a putative risk factor for adverse outcomes. The finding that maternal anxiety disorders before birth yielded less consistent associations, suggests that self-perceived distress during pregnancy might be seen as a putative moderator/mediator in the familial transmission of anxiety. SN - 1872-6232 UR - https://www.unboundmedicine.com/medline/citation/20547016/Anxiety_disorders_before_birth_and_self_perceived_distress_during_pregnancy:_associations_with_maternal_depression_and_obstetric_neonatal_and_early_childhood_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-3782(10)00087-3 DB - PRIME DP - Unbound Medicine ER -