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Gene exchange and the origin of giant viruses.
Intervirology. 2010; 53(5):354-61.I

Abstract

Giant viruses or nucleocytoplasmic large DNA viruses (NCLDVs) infect a wide range of eukaryotic hosts (including, algae, amoebae and metazoans) and show a very large range in genome size (between 100 kb and 1.2 Mb). Here we review some recent results concerning the extensive lateral gene transfer which appears to have occurred during NCLDV evolution. Current data suggest that giant viruses probably originated from a simple and ancient viral ancestor with a small subset of 30-35 genes encoding replication and structural proteins. A large array of lateral gene transfers from diverse cellular sources, including several families of mobile genetic elements, is probably responsible for the huge diversity of genome size and composition found in extant giant viruses.

Authors+Show Affiliations

Laboratoire Evolution, Génomes et Spéciation, CNRS UPR 9034, Gif sur Yvette, France. jonathan.filee@legs.cnrs-gif.frNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20551687

Citation

Filée, Jonathan, and Michael Chandler. "Gene Exchange and the Origin of Giant Viruses." Intervirology, vol. 53, no. 5, 2010, pp. 354-61.
Filée J, Chandler M. Gene exchange and the origin of giant viruses. Intervirology. 2010;53(5):354-61.
Filée, J., & Chandler, M. (2010). Gene exchange and the origin of giant viruses. Intervirology, 53(5), 354-61. https://doi.org/10.1159/000312920
Filée J, Chandler M. Gene Exchange and the Origin of Giant Viruses. Intervirology. 2010;53(5):354-61. PubMed PMID: 20551687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene exchange and the origin of giant viruses. AU - Filée,Jonathan, AU - Chandler,Michael, Y1 - 2010/06/15/ PY - 2010/6/17/entrez PY - 2010/6/17/pubmed PY - 2010/9/16/medline SP - 354 EP - 61 JF - Intervirology JO - Intervirology VL - 53 IS - 5 N2 - Giant viruses or nucleocytoplasmic large DNA viruses (NCLDVs) infect a wide range of eukaryotic hosts (including, algae, amoebae and metazoans) and show a very large range in genome size (between 100 kb and 1.2 Mb). Here we review some recent results concerning the extensive lateral gene transfer which appears to have occurred during NCLDV evolution. Current data suggest that giant viruses probably originated from a simple and ancient viral ancestor with a small subset of 30-35 genes encoding replication and structural proteins. A large array of lateral gene transfers from diverse cellular sources, including several families of mobile genetic elements, is probably responsible for the huge diversity of genome size and composition found in extant giant viruses. SN - 1423-0100 UR - https://www.unboundmedicine.com/medline/citation/20551687/Gene_exchange_and_the_origin_of_giant_viruses_ DB - PRIME DP - Unbound Medicine ER -