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Fingolimod is a potential novel therapy for multiple sclerosis.
Nat Rev Neurol 2010; 6(7):373-82NR

Abstract

Fingolimod (also known as FTY720) is an orally available sphingosine-1-phosphate (S1P) receptor modulator that has unique and potent immunoregulatory properties. Mechanistic studies indicate that on phosphorylation fingolimod can bind with high affinity to S1P(1) receptors. Persistent modulation of lymphocyte S1P(1) receptors by fingolimod and the subsequent internalization of these receptors inhibits lymphocyte egress from the lymph nodes, and prevents these cells from infiltrating inflammatory lesions in the CNS. Results of two phase III studies--FREEDOMS and TRANSFORMS--support previous phase II trial observations indicating that fingolimod exerts powerful anti-inflammatory effects in relapsing-remitting multiple sclerosis (MS). Fingolimod might, therefore, be one of the first orally active drug therapies available for the treatment of relapsing-remitting MS. Moreover, results from preclinical studies suggest that fingolimod might promote neural repair in vivo. In this article, we review the background to these findings, present the proposed immunological and neurobiological profile of fingolimod, discuss the data from the FREEDOMS and TRANSFORMS trials, and provide an expert opinion regarding the future of next-generation S1P receptor modulators for MS therapy.

Authors+Show Affiliations

Department of Neurology, Heinrich-Heine-University of Düsseldorf, 40225 Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20551946

Citation

Aktas, Orhan, et al. "Fingolimod Is a Potential Novel Therapy for Multiple Sclerosis." Nature Reviews. Neurology, vol. 6, no. 7, 2010, pp. 373-82.
Aktas O, Küry P, Kieseier B, et al. Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol. 2010;6(7):373-82.
Aktas, O., Küry, P., Kieseier, B., & Hartung, H. P. (2010). Fingolimod is a potential novel therapy for multiple sclerosis. Nature Reviews. Neurology, 6(7), pp. 373-82. doi:10.1038/nrneurol.2010.76.
Aktas O, et al. Fingolimod Is a Potential Novel Therapy for Multiple Sclerosis. Nat Rev Neurol. 2010;6(7):373-82. PubMed PMID: 20551946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fingolimod is a potential novel therapy for multiple sclerosis. AU - Aktas,Orhan, AU - Küry,Patrick, AU - Kieseier,Bernd, AU - Hartung,Hans-Peter, Y1 - 2010/06/15/ PY - 2010/6/17/entrez PY - 2010/6/17/pubmed PY - 2010/10/29/medline SP - 373 EP - 82 JF - Nature reviews. Neurology JO - Nat Rev Neurol VL - 6 IS - 7 N2 - Fingolimod (also known as FTY720) is an orally available sphingosine-1-phosphate (S1P) receptor modulator that has unique and potent immunoregulatory properties. Mechanistic studies indicate that on phosphorylation fingolimod can bind with high affinity to S1P(1) receptors. Persistent modulation of lymphocyte S1P(1) receptors by fingolimod and the subsequent internalization of these receptors inhibits lymphocyte egress from the lymph nodes, and prevents these cells from infiltrating inflammatory lesions in the CNS. Results of two phase III studies--FREEDOMS and TRANSFORMS--support previous phase II trial observations indicating that fingolimod exerts powerful anti-inflammatory effects in relapsing-remitting multiple sclerosis (MS). Fingolimod might, therefore, be one of the first orally active drug therapies available for the treatment of relapsing-remitting MS. Moreover, results from preclinical studies suggest that fingolimod might promote neural repair in vivo. In this article, we review the background to these findings, present the proposed immunological and neurobiological profile of fingolimod, discuss the data from the FREEDOMS and TRANSFORMS trials, and provide an expert opinion regarding the future of next-generation S1P receptor modulators for MS therapy. SN - 1759-4766 UR - https://www.unboundmedicine.com/medline/citation/20551946/Fingolimod_is_a_potential_novel_therapy_for_multiple_sclerosis_ L2 - http://dx.doi.org/10.1038/nrneurol.2010.76 DB - PRIME DP - Unbound Medicine ER -