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Preparation and application of a molecularly imprinted polymer for the determination of trace metolcarb in food matrices by high performance liquid chromatography.
J Sep Sci. 2010 Jul; 33(14):2079-85.JS

Abstract

In this article, for the first time, a molecularly imprinted polymer (MIP) for the metolcarb was prepared by bulk polymerization using metolcarb as the template, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The prepared polymer was characterized by FT-IR, static and kinetic adsorption experiments, and the results showed that it has been successfully synthesized and had good selective ability for metolcarb. The MIP was applied as a sorbent in molecularly imprinted SPE coupled with HPLC-UV for separation and determination of trace metolcarb in three kinds of food matrices at three concentration levels. Under the optimal conditions, the LODs (S/N=3) of cabbage, cucumber and pear were 7.622, 6.455 and 13.52 microg/kg, respectively, and recoveries were in the range of 68.80-101.31% with RSD (n=3) below 3.78% in all cases. To demonstrate further the selectivity of the MIP obtained, a comparison with commercially available C(18) SPE was performed. The results indicated that molecularly imprinted SPE showed better chromatography, better selectivity and higher recoveries for metolcarb than commercially available C(18) SPE.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Qian K
Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science & Technology, Tianjin, P. R. China.
Fang G
No affiliation info available
He J
No affiliation info available
Pan M
No affiliation info available
Wang S
No affiliation info available

MeSH

AdsorptionChromatography, High Pressure LiquidFood ContaminationMolecular ImprintingMolecular StructurePhenylcarbamatesPolymersSpectroscopy, Fourier Transform Infrared

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20552596

Citation

Qian, Kun, et al. "Preparation and Application of a Molecularly Imprinted Polymer for the Determination of Trace Metolcarb in Food Matrices By High Performance Liquid Chromatography." Journal of Separation Science, vol. 33, no. 14, 2010, pp. 2079-85.
Qian K, Fang G, He J, et al. Preparation and application of a molecularly imprinted polymer for the determination of trace metolcarb in food matrices by high performance liquid chromatography. J Sep Sci. 2010;33(14):2079-85.
Qian, K., Fang, G., He, J., Pan, M., & Wang, S. (2010). Preparation and application of a molecularly imprinted polymer for the determination of trace metolcarb in food matrices by high performance liquid chromatography. Journal of Separation Science, 33(14), 2079-85. https://doi.org/10.1002/jssc.200900877
Qian K, et al. Preparation and Application of a Molecularly Imprinted Polymer for the Determination of Trace Metolcarb in Food Matrices By High Performance Liquid Chromatography. J Sep Sci. 2010;33(14):2079-85. PubMed PMID: 20552596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and application of a molecularly imprinted polymer for the determination of trace metolcarb in food matrices by high performance liquid chromatography. AU - Qian,Kun, AU - Fang,Guozhen, AU - He,Jinxing, AU - Pan,Mingfei, AU - Wang,Shuo, PY - 2010/6/17/entrez PY - 2010/6/17/pubmed PY - 2010/10/20/medline SP - 2079 EP - 85 JF - Journal of separation science JO - J Sep Sci VL - 33 IS - 14 N2 - In this article, for the first time, a molecularly imprinted polymer (MIP) for the metolcarb was prepared by bulk polymerization using metolcarb as the template, methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker. The prepared polymer was characterized by FT-IR, static and kinetic adsorption experiments, and the results showed that it has been successfully synthesized and had good selective ability for metolcarb. The MIP was applied as a sorbent in molecularly imprinted SPE coupled with HPLC-UV for separation and determination of trace metolcarb in three kinds of food matrices at three concentration levels. Under the optimal conditions, the LODs (S/N=3) of cabbage, cucumber and pear were 7.622, 6.455 and 13.52 microg/kg, respectively, and recoveries were in the range of 68.80-101.31% with RSD (n=3) below 3.78% in all cases. To demonstrate further the selectivity of the MIP obtained, a comparison with commercially available C(18) SPE was performed. The results indicated that molecularly imprinted SPE showed better chromatography, better selectivity and higher recoveries for metolcarb than commercially available C(18) SPE. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/20552596/Preparation_and_application_of_a_molecularly_imprinted_polymer_for_the_determination_of_trace_metolcarb_in_food_matrices_by_high_performance_liquid_chromatography_ L2 - https://doi.org/10.1002/jssc.200900877 DB - PRIME DP - Unbound Medicine ER -