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Solitary epidermolytic acanthoma: a clinical and histopathological study.
J Eur Acad Dermatol Venereol. 2011 Feb; 25(2):175-80.JE

Abstract

BACKGROUND

Epidermolytic acanthoma (EA) is an uncommon cutaneous entity that typically presents as a solitary lesion, or, less commonly, as multiple or disseminated discrete lesions. It usually appears at or after middle-age, and has been reported in various locations including the face, trunk, extremities and genitalia. Histopathologically, EA shows epidermolytic hyperkeratosis (EHK) involving either the entire thickness of the epidermis or just the granular and upper spinous layers.

OBJECTIVE AND METHODS

To describe the clinical and microscopic features of EA, we retrospectively reviewed all cases diagnosed as EA at the Skin Pathology Laboratory at Boston University between 1999 and 2009.

RESULTS

Solitary EA is more common in men (65%) and usually presents as a hyperkeratotic papule on the trunk (45%) or extremities (25%). Histopathologically, all cases of solitary EA showed the classical features of hyperkeratosis, acanthosis and EHK. Three architectural patterns were observed on scanning magnification: papillomatous (55%), cup-shaped (40%) and acanthotic (15%). Additional common features encountered included focal parakeratosis (85%), and a sparse to mild superficial perivascular lymphocytic infiltrate (90%).

CONCLUSION

This large case series of solitary EA reviews the clinical features of this entity and describes several new histological variants.

Authors+Show Affiliations

Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, MA, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20553361

Citation

Abbas, O, et al. "Solitary Epidermolytic Acanthoma: a Clinical and Histopathological Study." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 25, no. 2, 2011, pp. 175-80.
Abbas O, Wieland CN, Goldberg LJ. Solitary epidermolytic acanthoma: a clinical and histopathological study. J Eur Acad Dermatol Venereol. 2011;25(2):175-80.
Abbas, O., Wieland, C. N., & Goldberg, L. J. (2011). Solitary epidermolytic acanthoma: a clinical and histopathological study. Journal of the European Academy of Dermatology and Venereology : JEADV, 25(2), 175-80. https://doi.org/10.1111/j.1468-3083.2010.03736.x
Abbas O, Wieland CN, Goldberg LJ. Solitary Epidermolytic Acanthoma: a Clinical and Histopathological Study. J Eur Acad Dermatol Venereol. 2011;25(2):175-80. PubMed PMID: 20553361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solitary epidermolytic acanthoma: a clinical and histopathological study. AU - Abbas,O, AU - Wieland,C N, AU - Goldberg,L J, Y1 - 2010/06/09/ PY - 2010/6/18/entrez PY - 2010/6/18/pubmed PY - 2011/4/16/medline SP - 175 EP - 80 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 25 IS - 2 N2 - BACKGROUND: Epidermolytic acanthoma (EA) is an uncommon cutaneous entity that typically presents as a solitary lesion, or, less commonly, as multiple or disseminated discrete lesions. It usually appears at or after middle-age, and has been reported in various locations including the face, trunk, extremities and genitalia. Histopathologically, EA shows epidermolytic hyperkeratosis (EHK) involving either the entire thickness of the epidermis or just the granular and upper spinous layers. OBJECTIVE AND METHODS: To describe the clinical and microscopic features of EA, we retrospectively reviewed all cases diagnosed as EA at the Skin Pathology Laboratory at Boston University between 1999 and 2009. RESULTS: Solitary EA is more common in men (65%) and usually presents as a hyperkeratotic papule on the trunk (45%) or extremities (25%). Histopathologically, all cases of solitary EA showed the classical features of hyperkeratosis, acanthosis and EHK. Three architectural patterns were observed on scanning magnification: papillomatous (55%), cup-shaped (40%) and acanthotic (15%). Additional common features encountered included focal parakeratosis (85%), and a sparse to mild superficial perivascular lymphocytic infiltrate (90%). CONCLUSION: This large case series of solitary EA reviews the clinical features of this entity and describes several new histological variants. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/20553361/Solitary_epidermolytic_acanthoma:_a_clinical_and_histopathological_study_ L2 - https://doi.org/10.1111/j.1468-3083.2010.03736.x DB - PRIME DP - Unbound Medicine ER -