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Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls.
J Alzheimers Dis 2010; 21(2):471-8JA

Abstract

Cystatin C is suggested to be involved in neurodegeneration and the development of Alzheimer's disease (AD) by binding to soluble amyloid-beta (Abeta) peptides. Studies of cystatin C levels in cerebrospinal fluid (CSF) in relation to risk of AD are conflicting and relations between cystatin C, Abeta42, and tau levels in CSF in AD, mild cognitive impairment (MCI), and healthy controls are unknown. The objective of this study was to investigate cystatin C, Abeta42, and tau levels in CSF in AD, MCI, and controls. As a secondary aim, the relationships between cystatin C, Abeta42, and tau levels across disease groups were investigated. Cystatin C, Abeta42, total tau, and phosphorylated tau levels in CSF were analyzed by turbidimetry (cystatin C) and xMAP Luminex technology (Abeta and tau) in persons with AD (n=101), MCI (n=84), and healthy control subjects (n=28). Mean cystatin C levels were similar in cases of AD (5.6 micromol/L +/- 1.7), MCI (5.4 micromol/L +/- 1.48), and controls (5.6 micromol/L +/- 1.6). However, CSF cystatin C levels were strongly and positively correlated with total tau and phosphorylated tau levels (r=0.61-0.81, p< 0.0001) and Abeta42 (r=0.35-0.65, p< 0.001) independent of age, gender, and APOE genotype. Mean CSF cystatin C levels did not differ between patients with AD and MCI and healthy controls. Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype.

Authors+Show Affiliations

Uppsala University, Department of Public Health/Geriatrics, Uppsala, Sweden. johan.sundelof@pubcare.uu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20555147

Citation

Sundelöf, Johan, et al. "Cystatin C Levels Are Positively Correlated With Both Abeta42 and Tau Levels in Cerebrospinal Fluid in Persons With Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls." Journal of Alzheimer's Disease : JAD, vol. 21, no. 2, 2010, pp. 471-8.
Sundelöf J, Sundström J, Hansson O, et al. Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls. J Alzheimers Dis. 2010;21(2):471-8.
Sundelöf, J., Sundström, J., Hansson, O., Eriksdotter-Jönhagen, M., Giedraitis, V., Larsson, A., ... Lannfelt, L. (2010). Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls. Journal of Alzheimer's Disease : JAD, 21(2), pp. 471-8. doi:10.3233/JAD-2010-091594.
Sundelöf J, et al. Cystatin C Levels Are Positively Correlated With Both Abeta42 and Tau Levels in Cerebrospinal Fluid in Persons With Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls. J Alzheimers Dis. 2010;21(2):471-8. PubMed PMID: 20555147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls. AU - Sundelöf,Johan, AU - Sundström,Johan, AU - Hansson,Oskar, AU - Eriksdotter-Jönhagen,Maria, AU - Giedraitis,Vilmantas, AU - Larsson,Anders, AU - Degerman-Gunnarsson,Malin, AU - Ingelsson,Martin, AU - Minthon,Lennart, AU - Blennow,Kaj, AU - Kilander,Lena, AU - Basun,Hans, AU - Lannfelt,Lars, PY - 2010/6/18/entrez PY - 2010/6/18/pubmed PY - 2010/12/21/medline SP - 471 EP - 8 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 21 IS - 2 N2 - Cystatin C is suggested to be involved in neurodegeneration and the development of Alzheimer's disease (AD) by binding to soluble amyloid-beta (Abeta) peptides. Studies of cystatin C levels in cerebrospinal fluid (CSF) in relation to risk of AD are conflicting and relations between cystatin C, Abeta42, and tau levels in CSF in AD, mild cognitive impairment (MCI), and healthy controls are unknown. The objective of this study was to investigate cystatin C, Abeta42, and tau levels in CSF in AD, MCI, and controls. As a secondary aim, the relationships between cystatin C, Abeta42, and tau levels across disease groups were investigated. Cystatin C, Abeta42, total tau, and phosphorylated tau levels in CSF were analyzed by turbidimetry (cystatin C) and xMAP Luminex technology (Abeta and tau) in persons with AD (n=101), MCI (n=84), and healthy control subjects (n=28). Mean cystatin C levels were similar in cases of AD (5.6 micromol/L +/- 1.7), MCI (5.4 micromol/L +/- 1.48), and controls (5.6 micromol/L +/- 1.6). However, CSF cystatin C levels were strongly and positively correlated with total tau and phosphorylated tau levels (r=0.61-0.81, p< 0.0001) and Abeta42 (r=0.35-0.65, p< 0.001) independent of age, gender, and APOE genotype. Mean CSF cystatin C levels did not differ between patients with AD and MCI and healthy controls. Interestingly, cystatin C levels were positively correlated with both tau and Abeta42 levels in CSF independent of age, gender, and APOE genotype. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20555147/Cystatin_C_levels_are_positively_correlated_with_both_Abeta42_and_tau_levels_in_cerebrospinal_fluid_in_persons_with_Alzheimer's_disease_mild_cognitive_impairment_and_healthy_controls_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-2010-091594 DB - PRIME DP - Unbound Medicine ER -