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High-intensity interval training increases SIRT1 activity in human skeletal muscle.
Appl Physiol Nutr Metab 2010; 35(3):350-7AP

Abstract

The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity and protein in relationship to peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial content were determined in human skeletal muscle. Six weeks of high-intensity interval training ( approximately 1 h of 10 x 4 min intervals at 90% peak oxygen consumption separated by 2 min rest, 3 days per week) increased maximal activities of mitochondrial enzymes in skeletal muscle by 28% to 36% (citrate synthase, beta-hydroxyacyl-coenzyme A dehydrogenase, and cytochrome c oxidase subunit IV) and PGC-1alpha protein (16%) when measured 4 days after training. Interestingly, total muscle SIRT1 activity (31%) and activity per SIRT1 protein (58%) increased despite decreased SIRT1 protein (20%). The present data demonstrate that exercise-induced mitochondrial biogenesis is accompanied by elevated SIRT1 activity in human skeletal muscle.

Authors+Show Affiliations

School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L 3N6, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20555380

Citation

Gurd, Brendon J., et al. "High-intensity Interval Training Increases SIRT1 Activity in Human Skeletal Muscle." Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, vol. 35, no. 3, 2010, pp. 350-7.
Gurd BJ, Perry CG, Heigenhauser GJ, et al. High-intensity interval training increases SIRT1 activity in human skeletal muscle. Appl Physiol Nutr Metab. 2010;35(3):350-7.
Gurd, B. J., Perry, C. G., Heigenhauser, G. J., Spriet, L. L., & Bonen, A. (2010). High-intensity interval training increases SIRT1 activity in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme, 35(3), pp. 350-7. doi:10.1139/H10-030.
Gurd BJ, et al. High-intensity Interval Training Increases SIRT1 Activity in Human Skeletal Muscle. Appl Physiol Nutr Metab. 2010;35(3):350-7. PubMed PMID: 20555380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-intensity interval training increases SIRT1 activity in human skeletal muscle. AU - Gurd,Brendon J, AU - Perry,Christopher G R, AU - Heigenhauser,George J F, AU - Spriet,Lawrence L, AU - Bonen,Arend, PY - 2010/6/18/entrez PY - 2010/6/18/pubmed PY - 2010/8/28/medline SP - 350 EP - 7 JF - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JO - Appl Physiol Nutr Metab VL - 35 IS - 3 N2 - The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity and protein in relationship to peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial content were determined in human skeletal muscle. Six weeks of high-intensity interval training ( approximately 1 h of 10 x 4 min intervals at 90% peak oxygen consumption separated by 2 min rest, 3 days per week) increased maximal activities of mitochondrial enzymes in skeletal muscle by 28% to 36% (citrate synthase, beta-hydroxyacyl-coenzyme A dehydrogenase, and cytochrome c oxidase subunit IV) and PGC-1alpha protein (16%) when measured 4 days after training. Interestingly, total muscle SIRT1 activity (31%) and activity per SIRT1 protein (58%) increased despite decreased SIRT1 protein (20%). The present data demonstrate that exercise-induced mitochondrial biogenesis is accompanied by elevated SIRT1 activity in human skeletal muscle. SN - 1715-5312 UR - https://www.unboundmedicine.com/medline/citation/20555380/High_intensity_interval_training_increases_SIRT1_activity_in_human_skeletal_muscle_ L2 - http://www.nrcresearchpress.com/doi/full/10.1139/H10-030?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -