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Evaluation of a matrix tablet prepared with polyacrylamide-g-sodium alginate co-polymers and their partially hydrolyzed co-polymers for sustained release of diltiazem hydrochloride.
J Biomater Sci Polym Ed. 2010; 21(13):1799-814.JB

Abstract

Diltiazem hydrochloride (DTZ) matrix tablets were prepared using polyacrylamide-grafted sodium alginate (PAam-g-SA) co-polymers having different percentages of grafting and their partially hydrolyzed products with a view to achieve sustained release of the highly water-soluble drug. PAam-g-SA co-polymers having different percentages of grafting were synthesized by free radical polymerization using acrylamide (Aam) as monomer and ammonium persulphate (APS) as initiator, and the resulting co-polymers were subjected to alkaline hydrolysis to produce their corresponding partially hydrolyzed co-polymers. Matrix tablets of DTZ were prepared by wet granulation using either PAam-g-SA co-polymers or partially hydrolyzed PAam-g-SA co-polymers. The effect of percentage grafting, drug load and calcium gluconate (CG), used as excipient, was studied in simulated gastrointestinal fluid. While the tablets prepared using the co-polymer having higher percentages of grafting provided faster drug release (100% in 5.5 h), the tablets prepared with the corresponding hydrolyzed co-polymer released the drug slowly (71% in 12 h). This behaviour in release appeared to be controlled by the relative magnitude of the viscosity and the swelling capacity of the copolymers. Moreover, increase in drug load tended to decrease the drug release from all types of tablets and increase in the amount of CG increased the drug release. FT-IR and DSC studies revealed the absence of any interaction between the drug and the co-polymers. The matrix tablet made of partially hydrolyzed graft co-polymer having the highest percentage of grafting provided the most sustained release of the drug.

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Authors+Show Affiliations

Mandal S
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Ray R
No affiliation info available
Basu SK
No affiliation info available
Sa B
No affiliation info available

MeSH

AcrylamideAcrylic ResinsAlginatesBiomimeticsCalcium GluconateCalorimetry, Differential ScanningChemistry, PharmaceuticalDelayed-Action PreparationsDiltiazemDrug InteractionsGastric JuiceGlucuronic AcidHexuronic AcidsHydrogen-Ion ConcentrationHydrolysisIntestinal MucosaSpectroscopy, Fourier Transform InfraredTabletsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20557689

Citation

Mandal, Sanchita, et al. "Evaluation of a Matrix Tablet Prepared With Polyacrylamide-g-sodium Alginate Co-polymers and Their Partially Hydrolyzed Co-polymers for Sustained Release of Diltiazem Hydrochloride." Journal of Biomaterials Science. Polymer Edition, vol. 21, no. 13, 2010, pp. 1799-814.
Mandal S, Ray R, Basu SK, et al. Evaluation of a matrix tablet prepared with polyacrylamide-g-sodium alginate co-polymers and their partially hydrolyzed co-polymers for sustained release of diltiazem hydrochloride. J Biomater Sci Polym Ed. 2010;21(13):1799-814.
Mandal, S., Ray, R., Basu, S. K., & Sa, B. (2010). Evaluation of a matrix tablet prepared with polyacrylamide-g-sodium alginate co-polymers and their partially hydrolyzed co-polymers for sustained release of diltiazem hydrochloride. Journal of Biomaterials Science. Polymer Edition, 21(13), 1799-814. https://doi.org/10.1163/092050609X12567183711214
Mandal S, et al. Evaluation of a Matrix Tablet Prepared With Polyacrylamide-g-sodium Alginate Co-polymers and Their Partially Hydrolyzed Co-polymers for Sustained Release of Diltiazem Hydrochloride. J Biomater Sci Polym Ed. 2010;21(13):1799-814. PubMed PMID: 20557689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a matrix tablet prepared with polyacrylamide-g-sodium alginate co-polymers and their partially hydrolyzed co-polymers for sustained release of diltiazem hydrochloride. AU - Mandal,Sanchita, AU - Ray,Rajat, AU - Basu,Sanat K, AU - Sa,Biswanath, Y1 - 2010/06/16/ PY - 2010/6/19/entrez PY - 2010/6/19/pubmed PY - 2011/4/2/medline SP - 1799 EP - 814 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 21 IS - 13 N2 - Diltiazem hydrochloride (DTZ) matrix tablets were prepared using polyacrylamide-grafted sodium alginate (PAam-g-SA) co-polymers having different percentages of grafting and their partially hydrolyzed products with a view to achieve sustained release of the highly water-soluble drug. PAam-g-SA co-polymers having different percentages of grafting were synthesized by free radical polymerization using acrylamide (Aam) as monomer and ammonium persulphate (APS) as initiator, and the resulting co-polymers were subjected to alkaline hydrolysis to produce their corresponding partially hydrolyzed co-polymers. Matrix tablets of DTZ were prepared by wet granulation using either PAam-g-SA co-polymers or partially hydrolyzed PAam-g-SA co-polymers. The effect of percentage grafting, drug load and calcium gluconate (CG), used as excipient, was studied in simulated gastrointestinal fluid. While the tablets prepared using the co-polymer having higher percentages of grafting provided faster drug release (100% in 5.5 h), the tablets prepared with the corresponding hydrolyzed co-polymer released the drug slowly (71% in 12 h). This behaviour in release appeared to be controlled by the relative magnitude of the viscosity and the swelling capacity of the copolymers. Moreover, increase in drug load tended to decrease the drug release from all types of tablets and increase in the amount of CG increased the drug release. FT-IR and DSC studies revealed the absence of any interaction between the drug and the co-polymers. The matrix tablet made of partially hydrolyzed graft co-polymer having the highest percentage of grafting provided the most sustained release of the drug. SN - 1568-5624 UR - https://www.unboundmedicine.com/medline/citation/20557689/Evaluation_of_a_matrix_tablet_prepared_with_polyacrylamide_g_sodium_alginate_co_polymers_and_their_partially_hydrolyzed_co_polymers_for_sustained_release_of_diltiazem_hydrochloride_ L2 - https://www.tandfonline.com/doi/full/10.1163/092050609X12567183711214 DB - PRIME DP - Unbound Medicine ER -