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Biosynthesis of andrographolide in Andrographis paniculata.
Phytochemistry. 2010 Aug; 71(11-12):1298-304.P

Abstract

Andrographolide, a diterpene lactone, is isolated from Andrographis paniculata which is well known for its medicinal properties. The biosynthetic route to andrographolide was studied using [1-(13)C]acetate, [2-(13)C]acetate and [1,6-(13)C(2)]glucose. The peak enrichment of eight carbon atoms in the (13)C NMR spectra of andrographolide suggested that deoxyxylulose pathway (DXP) is the major biosynthetic pathway to this diterpene. The contribution of the mevalonic acid pathway (MVA) is indicated by the observed (13)C-labeling pattern, and because the labeling patterns indicate a simultaneous contribution of both methyl erythritol phosphate (MEP) and MVA pathways it can be deduced that cross-talk occurs between plastids and cytoplasm.

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Authors+Show Affiliations

Srivastava N
Central Institute of Medicinal and Aromatic Plants, Lucknow 226 015, India.
Akhila A
No affiliation info available

MeSH

AndrographisDiterpenesIndiaMevalonic AcidMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant StemsPlants, MedicinalSugar Phosphates

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20557910

Citation

Srivastava, Nishi, and Anand Akhila. "Biosynthesis of Andrographolide in Andrographis Paniculata." Phytochemistry, vol. 71, no. 11-12, 2010, pp. 1298-304.
Srivastava N, Akhila A. Biosynthesis of andrographolide in Andrographis paniculata. Phytochemistry. 2010;71(11-12):1298-304.
Srivastava, N., & Akhila, A. (2010). Biosynthesis of andrographolide in Andrographis paniculata. Phytochemistry, 71(11-12), 1298-304. https://doi.org/10.1016/j.phytochem.2010.05.022
Srivastava N, Akhila A. Biosynthesis of Andrographolide in Andrographis Paniculata. Phytochemistry. 2010;71(11-12):1298-304. PubMed PMID: 20557910.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biosynthesis of andrographolide in Andrographis paniculata. AU - Srivastava,Nishi, AU - Akhila,Anand, Y1 - 2010/06/16/ PY - 2010/04/07/received PY - 2010/05/25/revised PY - 2010/05/25/accepted PY - 2010/6/19/entrez PY - 2010/6/19/pubmed PY - 2010/10/12/medline SP - 1298 EP - 304 JF - Phytochemistry JO - Phytochemistry VL - 71 IS - 11-12 N2 - Andrographolide, a diterpene lactone, is isolated from Andrographis paniculata which is well known for its medicinal properties. The biosynthetic route to andrographolide was studied using [1-(13)C]acetate, [2-(13)C]acetate and [1,6-(13)C(2)]glucose. The peak enrichment of eight carbon atoms in the (13)C NMR spectra of andrographolide suggested that deoxyxylulose pathway (DXP) is the major biosynthetic pathway to this diterpene. The contribution of the mevalonic acid pathway (MVA) is indicated by the observed (13)C-labeling pattern, and because the labeling patterns indicate a simultaneous contribution of both methyl erythritol phosphate (MEP) and MVA pathways it can be deduced that cross-talk occurs between plastids and cytoplasm. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/20557910/Biosynthesis_of_andrographolide_in_Andrographis_paniculata_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(10)00216-5 DB - PRIME DP - Unbound Medicine ER -