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Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study.

Abstract

OBJECTIVE

To investigate the risk of open-angle glaucoma (OAG) after a diagnosis of hypothyroidism.

DESIGN

A retrospective, population-based follow-up study using an administrative database.

PARTICIPANTS

The study group comprised 257 hypothyroidism patients. The comparison group included 2056 subjects.

METHODS

Data were retrospectively collected from the Taiwan Longitudinal Health Insurance Database. The study cohort comprised patients aged ≥ 60 who received a first diagnosis of hypothyroidism (International Classification of Diseases, Ninth Revision, Clinical Modification code 244.9) from 1997 to 2001 (n = 257). The comparison cohort consisted of randomly selected patients without hypothyroidism who were aged ≥ 60 and had no diagnosis of glaucoma before 2001 (8 for every OAG patient; n = 2056). Each sampled patient was tracked for 5 years from their index visit. Cox proportional hazard regressions were used to compute the 5-year OAG-free survival rate, after adjusting for possible confounding factors.

MAIN OUTCOME MEASURES

The risk of developing OAG during the 5-year follow-up period.

RESULTS

Open-angle glaucoma developed in 7.4% of patients with hypothyroidism and 3.8% of patients in the comparison cohort during the follow-up period. Hypothyroid patients had a significantly lower 5-year OAG-free survival rate than patients in the comparison cohort. After adjusting for patients' age, gender, monthly income, urbanization level, and comorbid medical disorders, hypothyroidism patients were found to have a 1.78-fold (95% confidence interval [CI], 1.04-3.06) greater risk of developing OAG than the comparison cohort. This association remained significant in untreated hypothyroidism patients (adjusted hazard ratio [HR], 2.37; 95% CI, 1.10-5.09) and became statistically nonsignificant in patients treated with levothyroxine (adjusted HR, 1.73; 95% CI, 0.89-3.38).

CONCLUSIONS

Hypothyroid patients had a significantly increased risk of OAG development during the 5-year follow-up period. Levothyroxine seemed to be protective.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan.

    , ,

    Source

    Ophthalmology 117:10 2010 Oct pg 1960-6

    MeSH

    Aged
    Disease-Free Survival
    Female
    Follow-Up Studies
    Glaucoma, Open-Angle
    Humans
    Hypothyroidism
    Male
    Middle Aged
    Proportional Hazards Models
    Retrospective Studies
    Risk Factors
    Thyroxine

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20557938

    Citation

    Lin, Herng-Ching, et al. "Hypothyroidism and the Risk of Developing Open-angle Glaucoma: a Five-year Population-based Follow-up Study." Ophthalmology, vol. 117, no. 10, 2010, pp. 1960-6.
    Lin HC, Kang JH, Jiang YD, et al. Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study. Ophthalmology. 2010;117(10):1960-6.
    Lin, H. C., Kang, J. H., Jiang, Y. D., & Ho, J. D. (2010). Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study. Ophthalmology, 117(10), pp. 1960-6. doi:10.1016/j.ophtha.2010.02.005.
    Lin HC, et al. Hypothyroidism and the Risk of Developing Open-angle Glaucoma: a Five-year Population-based Follow-up Study. Ophthalmology. 2010;117(10):1960-6. PubMed PMID: 20557938.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hypothyroidism and the risk of developing open-angle glaucoma: a five-year population-based follow-up study. AU - Lin,Herng-Ching, AU - Kang,Jiunn-Horng, AU - Jiang,Yi-Der, AU - Ho,Jau-Der, Y1 - 2010/06/16/ PY - 2009/09/04/received PY - 2010/01/22/revised PY - 2010/02/02/accepted PY - 2010/6/19/entrez PY - 2010/6/19/pubmed PY - 2010/10/21/medline SP - 1960 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 117 IS - 10 N2 - OBJECTIVE: To investigate the risk of open-angle glaucoma (OAG) after a diagnosis of hypothyroidism. DESIGN: A retrospective, population-based follow-up study using an administrative database. PARTICIPANTS: The study group comprised 257 hypothyroidism patients. The comparison group included 2056 subjects. METHODS: Data were retrospectively collected from the Taiwan Longitudinal Health Insurance Database. The study cohort comprised patients aged ≥ 60 who received a first diagnosis of hypothyroidism (International Classification of Diseases, Ninth Revision, Clinical Modification code 244.9) from 1997 to 2001 (n = 257). The comparison cohort consisted of randomly selected patients without hypothyroidism who were aged ≥ 60 and had no diagnosis of glaucoma before 2001 (8 for every OAG patient; n = 2056). Each sampled patient was tracked for 5 years from their index visit. Cox proportional hazard regressions were used to compute the 5-year OAG-free survival rate, after adjusting for possible confounding factors. MAIN OUTCOME MEASURES: The risk of developing OAG during the 5-year follow-up period. RESULTS: Open-angle glaucoma developed in 7.4% of patients with hypothyroidism and 3.8% of patients in the comparison cohort during the follow-up period. Hypothyroid patients had a significantly lower 5-year OAG-free survival rate than patients in the comparison cohort. After adjusting for patients' age, gender, monthly income, urbanization level, and comorbid medical disorders, hypothyroidism patients were found to have a 1.78-fold (95% confidence interval [CI], 1.04-3.06) greater risk of developing OAG than the comparison cohort. This association remained significant in untreated hypothyroidism patients (adjusted hazard ratio [HR], 2.37; 95% CI, 1.10-5.09) and became statistically nonsignificant in patients treated with levothyroxine (adjusted HR, 1.73; 95% CI, 0.89-3.38). CONCLUSIONS: Hypothyroid patients had a significantly increased risk of OAG development during the 5-year follow-up period. Levothyroxine seemed to be protective. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/20557938/Hypothyroidism_and_the_risk_of_developing_open_angle_glaucoma:_a_five_year_population_based_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(10)00138-7 DB - PRIME DP - Unbound Medicine ER -