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Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet.
Exp Biol Med (Maywood) 2010; 235(7):849-56EB

Abstract

Because gut microbiota has recently attracted much attention as an environmental factor involved in the development of obesity, probiotics may be useful in preventing and/or improving obesity and its related disorders. The present study aimed to investigate the effects of Lactobacillus plantarum strain No. 14 (LP14), a bacterial strain reported to decrease body fat percentage in healthy volunteers, on adipocyte size in mice. Female C57BL/6 mice were fed either normal- or high-fat diet and administered intragastrically with LP14 (1 x 10(8) colony-forming units/mouse) or vehicle daily for 11 weeks. High dietary fat intake increased body weight gain, white adipose tissue weight, mean adipocyte size and serum total cholesterol and leptin concentrations, and decreased serum adiponectin concentration. In mice fed the high-fat diet, LP14 administration significantly reduced the mean adipocyte size and tended to reduce the white adipose tissue weight and serum total cholesterol and leptin concentrations as compared with the vehicle-administered mice. All mice had undetectable serum levels of conjugated linoleic acids that reportedly exert antiobesity action. In a separate experiment, LP14 ingestion had no influence on serum triacylglycerol accumulation following olive oil administration in Triton WR1339-treated mice, suggesting that dietary fat absorption is unaffected by LP14. In conclusion, we propose that LP14 may exert a beneficial effect on the onset of diet-induced obesity by reducing the cell size of white adipose tissues, and it seems unlikely that previously reported mechanisms for other bacterial strains are involved in the action of LP14.

Authors+Show Affiliations

Graduate School of Life Science, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo, Hokkaido, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20558839

Citation

Takemura, Naoki, et al. "Lactobacillus Plantarum Strain No. 14 Reduces Adipocyte Size in Mice Fed High-fat Diet." Experimental Biology and Medicine (Maywood, N.J.), vol. 235, no. 7, 2010, pp. 849-56.
Takemura N, Okubo T, Sonoyama K. Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Exp Biol Med (Maywood). 2010;235(7):849-56.
Takemura, N., Okubo, T., & Sonoyama, K. (2010). Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Experimental Biology and Medicine (Maywood, N.J.), 235(7), pp. 849-56. doi:10.1258/ebm.2010.009377.
Takemura N, Okubo T, Sonoyama K. Lactobacillus Plantarum Strain No. 14 Reduces Adipocyte Size in Mice Fed High-fat Diet. Exp Biol Med (Maywood). 2010;235(7):849-56. PubMed PMID: 20558839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. AU - Takemura,Naoki, AU - Okubo,Takuma, AU - Sonoyama,Kei, PY - 2010/6/19/entrez PY - 2010/6/19/pubmed PY - 2010/7/10/medline SP - 849 EP - 56 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp. Biol. Med. (Maywood) VL - 235 IS - 7 N2 - Because gut microbiota has recently attracted much attention as an environmental factor involved in the development of obesity, probiotics may be useful in preventing and/or improving obesity and its related disorders. The present study aimed to investigate the effects of Lactobacillus plantarum strain No. 14 (LP14), a bacterial strain reported to decrease body fat percentage in healthy volunteers, on adipocyte size in mice. Female C57BL/6 mice were fed either normal- or high-fat diet and administered intragastrically with LP14 (1 x 10(8) colony-forming units/mouse) or vehicle daily for 11 weeks. High dietary fat intake increased body weight gain, white adipose tissue weight, mean adipocyte size and serum total cholesterol and leptin concentrations, and decreased serum adiponectin concentration. In mice fed the high-fat diet, LP14 administration significantly reduced the mean adipocyte size and tended to reduce the white adipose tissue weight and serum total cholesterol and leptin concentrations as compared with the vehicle-administered mice. All mice had undetectable serum levels of conjugated linoleic acids that reportedly exert antiobesity action. In a separate experiment, LP14 ingestion had no influence on serum triacylglycerol accumulation following olive oil administration in Triton WR1339-treated mice, suggesting that dietary fat absorption is unaffected by LP14. In conclusion, we propose that LP14 may exert a beneficial effect on the onset of diet-induced obesity by reducing the cell size of white adipose tissues, and it seems unlikely that previously reported mechanisms for other bacterial strains are involved in the action of LP14. SN - 1535-3699 UR - https://www.unboundmedicine.com/medline/citation/20558839/Lactobacillus_plantarum_strain_No__14_reduces_adipocyte_size_in_mice_fed_high_fat_diet_ L2 - http://journals.sagepub.com/doi/full/10.1258/ebm.2010.009377?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -