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Hereditary colon cancer: lynch syndrome.
Gut Liver 2010; 4(2):151-60GL

Abstract

Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome.

Authors+Show Affiliations

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20559516

Citation

Jang, Eunjeong, and Daniel C. Chung. "Hereditary Colon Cancer: Lynch Syndrome." Gut and Liver, vol. 4, no. 2, 2010, pp. 151-60.
Jang E, Chung DC. Hereditary colon cancer: lynch syndrome. Gut Liver. 2010;4(2):151-60.
Jang, E., & Chung, D. C. (2010). Hereditary colon cancer: lynch syndrome. Gut and Liver, 4(2), pp. 151-60. doi:10.5009/gnl.2010.4.2.151.
Jang E, Chung DC. Hereditary Colon Cancer: Lynch Syndrome. Gut Liver. 2010;4(2):151-60. PubMed PMID: 20559516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary colon cancer: lynch syndrome. AU - Jang,Eunjeong, AU - Chung,Daniel C, Y1 - 2010/06/16/ PY - 2010/02/04/received PY - 2010/03/15/accepted PY - 2010/6/19/entrez PY - 2010/6/19/pubmed PY - 2010/6/19/medline KW - Colon cancer KW - Hereditary nonpolyposis colon cancer KW - Immunohistochemistry KW - Lynch syndrome KW - Microsatellite instability KW - Mismatch repair gene SP - 151 EP - 60 JF - Gut and liver JO - Gut Liver VL - 4 IS - 2 N2 - Lynch syndrome is the most common familial colorectal cancer syndrome. It is linked to germline mutations in one of four DNA mismatch repair (MMR) genes. A comprehensive family history is one important way to identify at-risk individuals. The elucidation of the molecular genetics of this syndrome has made it possible to screen for the disorder with molecular tests. Microsatellite instability and/or immunohistochemistry followed by germline testing for mutations in MMR genes is now a standard approach for clinically suspected cases. Correctly recognizing Lynch syndrome is essential for the application of appropriate screening and surveillance measures. Close surveillance and risk-reducing operations can decrease cancer-related mortality. In addition, counseling is an important component of the management of any family with Lynch syndrome. SN - 2005-1212 UR - https://www.unboundmedicine.com/medline/citation/20559516/Hereditary_colon_cancer:_lynch_syndrome_ L2 - http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl.2010.4.2.151 DB - PRIME DP - Unbound Medicine ER -