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Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man.
J Clin Invest. 1991 Jul; 88(1):27-33.JCI

Abstract

To investigate the mechanism(s) of insulin-induced suppression of plasma amino acid concentration and release, we studied forearm as well as whole-body leucine and phenylalanine uptake and release during a peripheral insulin infusion in postabsorptive normal subjects using isotope-dilution methods. Before insulin, leucine and phenylalanine release exceeded uptake (P less than 0.01 and P less than 0.07, respectively). A net output of alpha-ketoisocaproate (KIC) was also observed. During insulin, arterial plasma leucine, KIC and phenylalanine concentrations decreased (P less than 0.05 or less vs. basal), despite ongoing net output of these substrates by the forearm, that persisted after correction for the mean transit time spent through the extracellular muscular space. By the end of insulin, whole-body leucine and phenylalanine concentrations and rate of appearance were decreased (P less than 0.01 vs. basal). However, release and uptake of both amino acids by the forearm were not significantly decreased vs. the preinsulin values. These data indicate that systemic hyperinsulinemia acutely decreases plasma amino acid concentrations by acting primarily at sites other than skeletal muscle.

Authors+Show Affiliations

Department of Metabolic Diseases, University of Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2056121

Citation

Tessari, P, et al. "Effects of Acute Systemic Hyperinsulinemia On Forearm Muscle Proteolysis in Healthy Man." The Journal of Clinical Investigation, vol. 88, no. 1, 1991, pp. 27-33.
Tessari P, Inchiostro S, Biolo G, et al. Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man. J Clin Invest. 1991;88(1):27-33.
Tessari, P., Inchiostro, S., Biolo, G., Vincenti, E., & Sabadin, L. (1991). Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man. The Journal of Clinical Investigation, 88(1), 27-33.
Tessari P, et al. Effects of Acute Systemic Hyperinsulinemia On Forearm Muscle Proteolysis in Healthy Man. J Clin Invest. 1991;88(1):27-33. PubMed PMID: 2056121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute systemic hyperinsulinemia on forearm muscle proteolysis in healthy man. AU - Tessari,P, AU - Inchiostro,S, AU - Biolo,G, AU - Vincenti,E, AU - Sabadin,L, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 27 EP - 33 JF - The Journal of clinical investigation JO - J Clin Invest VL - 88 IS - 1 N2 - To investigate the mechanism(s) of insulin-induced suppression of plasma amino acid concentration and release, we studied forearm as well as whole-body leucine and phenylalanine uptake and release during a peripheral insulin infusion in postabsorptive normal subjects using isotope-dilution methods. Before insulin, leucine and phenylalanine release exceeded uptake (P less than 0.01 and P less than 0.07, respectively). A net output of alpha-ketoisocaproate (KIC) was also observed. During insulin, arterial plasma leucine, KIC and phenylalanine concentrations decreased (P less than 0.05 or less vs. basal), despite ongoing net output of these substrates by the forearm, that persisted after correction for the mean transit time spent through the extracellular muscular space. By the end of insulin, whole-body leucine and phenylalanine concentrations and rate of appearance were decreased (P less than 0.01 vs. basal). However, release and uptake of both amino acids by the forearm were not significantly decreased vs. the preinsulin values. These data indicate that systemic hyperinsulinemia acutely decreases plasma amino acid concentrations by acting primarily at sites other than skeletal muscle. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/2056121/Effects_of_acute_systemic_hyperinsulinemia_on_forearm_muscle_proteolysis_in_healthy_man_ DB - PRIME DP - Unbound Medicine ER -