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Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women.
Atherosclerosis. 2010 Sep; 212(1):339-44.A

Abstract

OBJECTIVE

The purpose of this study was to investigate the acute effects of dietary whey proteins on lipids, glucose and insulin, and resting energy expenditure in overweight and obese post-menopausal women, a population highly susceptible to cardiovascular disease.

METHODS

A three-way crossover design study was conducted where 20 overweight or obese, post-menopausal women were randomised to consume either 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control in conjunction with a breakfast meal. Blood samples were taken for up to 6 h.

RESULTS

There was no significant change in postprandial incremental area under the curve (AUC) for total cholesterol, low density lipoprotein, high density lipoprotein, non-esterified fatty acids, Apo B48, insulin and leptin between groups. However, there was a significant decrease in the appearance of triglycerides (TG) in the blood by 21% and 27% after consuming the whey meal compared to control and casein meals, respectively, as measured by AUC. There was also a significant reduction by 27% and 32% in the AUC for TG:ApoB48 ratio in the whey group compared to the glucose and casein groups, respectively. There was a significantly lower AUC for blood glucose after the consumption of the whey and casein meal compared to glucose meal.

CONCLUSION

These findings suggest that a single dose of whey protein can decrease arterial exposure to smaller TG-enriched lipoprotein particles compared to the glucose and casein meals in the postprandial period in overweight and obese, post-menopausal women.

Authors+Show Affiliations

School of Public Health, Curtin Health Innovation Research Institute, ATN Centre for Metabolic Fitness, Curtin University of Technology, Perth, Western Australia, Australia. pal@curtin.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20561625

Citation

Pal, Sebely, et al. "Acute Effects of Whey Protein Isolate On Cardiovascular Risk Factors in Overweight, Post-menopausal Women." Atherosclerosis, vol. 212, no. 1, 2010, pp. 339-44.
Pal S, Ellis V, Ho S. Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. Atherosclerosis. 2010;212(1):339-44.
Pal, S., Ellis, V., & Ho, S. (2010). Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. Atherosclerosis, 212(1), 339-44. https://doi.org/10.1016/j.atherosclerosis.2010.05.032
Pal S, Ellis V, Ho S. Acute Effects of Whey Protein Isolate On Cardiovascular Risk Factors in Overweight, Post-menopausal Women. Atherosclerosis. 2010;212(1):339-44. PubMed PMID: 20561625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. AU - Pal,Sebely, AU - Ellis,Vanessa, AU - Ho,Suleen, Y1 - 2010/05/31/ PY - 2010/01/21/received PY - 2010/04/12/revised PY - 2010/05/22/accepted PY - 2010/6/22/entrez PY - 2010/6/22/pubmed PY - 2010/12/29/medline SP - 339 EP - 44 JF - Atherosclerosis JO - Atherosclerosis VL - 212 IS - 1 N2 - OBJECTIVE: The purpose of this study was to investigate the acute effects of dietary whey proteins on lipids, glucose and insulin, and resting energy expenditure in overweight and obese post-menopausal women, a population highly susceptible to cardiovascular disease. METHODS: A three-way crossover design study was conducted where 20 overweight or obese, post-menopausal women were randomised to consume either 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control in conjunction with a breakfast meal. Blood samples were taken for up to 6 h. RESULTS: There was no significant change in postprandial incremental area under the curve (AUC) for total cholesterol, low density lipoprotein, high density lipoprotein, non-esterified fatty acids, Apo B48, insulin and leptin between groups. However, there was a significant decrease in the appearance of triglycerides (TG) in the blood by 21% and 27% after consuming the whey meal compared to control and casein meals, respectively, as measured by AUC. There was also a significant reduction by 27% and 32% in the AUC for TG:ApoB48 ratio in the whey group compared to the glucose and casein groups, respectively. There was a significantly lower AUC for blood glucose after the consumption of the whey and casein meal compared to glucose meal. CONCLUSION: These findings suggest that a single dose of whey protein can decrease arterial exposure to smaller TG-enriched lipoprotein particles compared to the glucose and casein meals in the postprandial period in overweight and obese, post-menopausal women. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/20561625/Acute_effects_of_whey_protein_isolate_on_cardiovascular_risk_factors_in_overweight_post_menopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(10)00410-7 DB - PRIME DP - Unbound Medicine ER -