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Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy.
Am J Ther 2010 Jul-Aug; 17(4):418-39AJ

Abstract

Fibromyalgia is a complex condition that is characterized by chronic widespread pain and multiple other symptoms, including fatigue, sleep disturbances, cognitive dysfunction, stiffness, and depressive episodes. Fibromyalgia may coexist and/or overlap with other conditions that may involve central sensitivity, including chronic fatigue syndrome, irritable bowel syndrome, irritable bladder syndrome or interstitial cystitis, and temporomandibular disorder. The pathophysiology of fibromyalgia remains uncertain but is believed to be partly the result of central systems affecting afferent processing as well as impaired endogenous pain-inhibitory systems. Abnormal central nociceptive processing may contribute to fibromyalgia, producing heightened responses to various noxious stimuli with resulting mechanical hyperalgesia. Fibromyalgia remains a clinical diagnosis. There has been a recent paradigm shift away from requiring 11 or more out of 18 tender points and instead focusing on the presence of chronic widespread pain as well as symptoms of fatigue, unrefreshed sleep, and other somatic complaints. Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [eg, duloxetine, milnacipran] and alpha 2-delta receptor ligands [eg, pregabalin]) may improve symptoms as well as function of patients with fibromyalgia.

Authors+Show Affiliations

Albany Medical College, Department of Anesthesiology, Albany, NY 12208, USA. smithh@mail.amc.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20562596

Citation

Smith, Howard S., and Robert L. Barkin. "Fibromyalgia Syndrome: a Discussion of the Syndrome and Pharmacotherapy." American Journal of Therapeutics, vol. 17, no. 4, 2010, pp. 418-39.
Smith HS, Barkin RL. Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy. Am J Ther. 2010;17(4):418-39.
Smith, H. S., & Barkin, R. L. (2010). Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy. American Journal of Therapeutics, 17(4), pp. 418-39. doi:10.1097/MJT.0b013e3181df8e1b.
Smith HS, Barkin RL. Fibromyalgia Syndrome: a Discussion of the Syndrome and Pharmacotherapy. Am J Ther. 2010;17(4):418-39. PubMed PMID: 20562596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibromyalgia syndrome: a discussion of the syndrome and pharmacotherapy. AU - Smith,Howard S, AU - Barkin,Robert L, PY - 2010/6/22/entrez PY - 2010/6/22/pubmed PY - 2010/10/23/medline SP - 418 EP - 39 JF - American journal of therapeutics JO - Am J Ther VL - 17 IS - 4 N2 - Fibromyalgia is a complex condition that is characterized by chronic widespread pain and multiple other symptoms, including fatigue, sleep disturbances, cognitive dysfunction, stiffness, and depressive episodes. Fibromyalgia may coexist and/or overlap with other conditions that may involve central sensitivity, including chronic fatigue syndrome, irritable bowel syndrome, irritable bladder syndrome or interstitial cystitis, and temporomandibular disorder. The pathophysiology of fibromyalgia remains uncertain but is believed to be partly the result of central systems affecting afferent processing as well as impaired endogenous pain-inhibitory systems. Abnormal central nociceptive processing may contribute to fibromyalgia, producing heightened responses to various noxious stimuli with resulting mechanical hyperalgesia. Fibromyalgia remains a clinical diagnosis. There has been a recent paradigm shift away from requiring 11 or more out of 18 tender points and instead focusing on the presence of chronic widespread pain as well as symptoms of fatigue, unrefreshed sleep, and other somatic complaints. Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies (serotonin norepinephrine reuptake inhibitors [eg, duloxetine, milnacipran] and alpha 2-delta receptor ligands [eg, pregabalin]) may improve symptoms as well as function of patients with fibromyalgia. SN - 1536-3686 UR - https://www.unboundmedicine.com/medline/citation/20562596/Fibromyalgia_syndrome:_a_discussion_of_the_syndrome_and_pharmacotherapy_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=20562596.ui DB - PRIME DP - Unbound Medicine ER -