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Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures.
J Bone Miner Res. 2010 Dec; 25(12):2572-81.JB

Abstract

Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) has been shown to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Women with (n = 68) and without (n = 101) a history of postmenopausal fragility fracture had aBMD measured by DXA and trabecular and cortical vBMD and trabecular microarchitecture of the radius and tibia measured by HR-pQCT. Finite-element analysis (FEA) of HR-pQCT scans was performed to estimate bone stiffness. DXA T-scores were similar in women with and without fracture at the spine, hip, and one-third radius but lower in patients with fracture at the ultradistal radius (p < .01). At the radius fracture, patients had lower total density, cortical thickness, trabecular density, number, thickness, higher trabecular separation and network heterogeneity (p < .0001 to .04). At the tibia, total, cortical, and trabecular density and cortical and trabecular thickness were lower in fracture patients (p < .0001 to .03). The differences between groups were greater at the radius than at the tibia for inner trabecular density, number, trabecular separation, and network heterogeneity (p < .01 to .05). Stiffness was reduced in fracture patients, more markedly at the radius (41% to 44%) than at the tibia (15% to 20%). Women with fractures had reduced vBMD, microarchitectural deterioration, and decreased strength. These differences were more prominent at the radius than at the tibia. HR-pQCT and FEA measurements of peripheral sites are associated with fracture prevalence and may increase understanding of the role of microarchitectural deterioration in fracture susceptibility. © 2010 American Society for Bone and Mineral Research.

Authors+Show Affiliations

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20564238

Citation

Stein, Emily M., et al. "Abnormal Microarchitecture and Reduced Stiffness at the Radius and Tibia in Postmenopausal Women With Fractures." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 25, no. 12, 2010, pp. 2572-81.
Stein EM, Liu XS, Nickolas TL, et al. Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res. 2010;25(12):2572-81.
Stein, E. M., Liu, X. S., Nickolas, T. L., Cohen, A., Thomas, V., McMahon, D. J., Zhang, C., Yin, P. T., Cosman, F., Nieves, J., Guo, X. E., & Shane, E. (2010). Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 25(12), 2572-81. https://doi.org/10.1002/jbmr.152
Stein EM, et al. Abnormal Microarchitecture and Reduced Stiffness at the Radius and Tibia in Postmenopausal Women With Fractures. J Bone Miner Res. 2010;25(12):2572-81. PubMed PMID: 20564238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. AU - Stein,Emily M, AU - Liu,X Sherry, AU - Nickolas,Thomas L, AU - Cohen,Adi, AU - Thomas,Valerie, AU - McMahon,Donald J, AU - Zhang,Chiyuan, AU - Yin,Perry T, AU - Cosman,Felicia, AU - Nieves,Jeri, AU - Guo,X Edward, AU - Shane,Elizabeth, Y1 - 2010/06/18/ PY - 2010/03/01/received PY - 2010/05/12/revised PY - 2010/06/04/accepted PY - 2010/6/22/entrez PY - 2010/6/22/pubmed PY - 2011/3/3/medline SP - 2572 EP - 81 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 25 IS - 12 N2 - Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) has been shown to predict fracture risk. High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility. Women with (n = 68) and without (n = 101) a history of postmenopausal fragility fracture had aBMD measured by DXA and trabecular and cortical vBMD and trabecular microarchitecture of the radius and tibia measured by HR-pQCT. Finite-element analysis (FEA) of HR-pQCT scans was performed to estimate bone stiffness. DXA T-scores were similar in women with and without fracture at the spine, hip, and one-third radius but lower in patients with fracture at the ultradistal radius (p < .01). At the radius fracture, patients had lower total density, cortical thickness, trabecular density, number, thickness, higher trabecular separation and network heterogeneity (p < .0001 to .04). At the tibia, total, cortical, and trabecular density and cortical and trabecular thickness were lower in fracture patients (p < .0001 to .03). The differences between groups were greater at the radius than at the tibia for inner trabecular density, number, trabecular separation, and network heterogeneity (p < .01 to .05). Stiffness was reduced in fracture patients, more markedly at the radius (41% to 44%) than at the tibia (15% to 20%). Women with fractures had reduced vBMD, microarchitectural deterioration, and decreased strength. These differences were more prominent at the radius than at the tibia. HR-pQCT and FEA measurements of peripheral sites are associated with fracture prevalence and may increase understanding of the role of microarchitectural deterioration in fracture susceptibility. © 2010 American Society for Bone and Mineral Research. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/20564238/Abnormal_microarchitecture_and_reduced_stiffness_at_the_radius_and_tibia_in_postmenopausal_women_with_fractures_ L2 - https://doi.org/10.1002/jbmr.152 DB - PRIME DP - Unbound Medicine ER -