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Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L.
Phytother Res. 2010 Dec; 24(12):1807-12.PR

Abstract

The antinociceptive and antiinflammatory activities of the ethanol extract of the aerial part of Urtica urens were determined by experimental animal models. U. urens extract was found to possess significant antinociceptive activity in chemically induced mouse pain models (ED₅₀ 39.3 mg/kg: 17.2-74.5 mg/kg) in the writhing test and 62.8% inhibition of the licking time in the late phase of the formalin test at a dose of 500 mg/kg p.o. and antiinflammatory activity on carrageenan-induced rat hind paw edema (41.5% inhibition at a dose of 300 mg/kg i.p.). The extract displayed activity neither in the thermal model of pain nor in the topical inflammation model. The major component of the extract was determined as chlorogenic acid (670 mg/1000 g dry weight) and could be partly responsible for this activity.

Authors+Show Affiliations

Cátedra de Farmacognosia, IQUIMEFA, Universidad de Buenos Aires, CONICET, Junín 956, C1113AAD Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20564509

Citation

Marrassini, Carla, et al. "Evaluation of Antinociceptive, Antinflammatory Activities and Phytochemical Analysis of Aerial Parts of Urtica Urens L." Phytotherapy Research : PTR, vol. 24, no. 12, 2010, pp. 1807-12.
Marrassini C, Acevedo C, Miño J, et al. Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. Phytother Res. 2010;24(12):1807-12.
Marrassini, C., Acevedo, C., Miño, J., Ferraro, G., & Gorzalczany, S. (2010). Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. Phytotherapy Research : PTR, 24(12), 1807-12. https://doi.org/10.1002/ptr.3188
Marrassini C, et al. Evaluation of Antinociceptive, Antinflammatory Activities and Phytochemical Analysis of Aerial Parts of Urtica Urens L. Phytother Res. 2010;24(12):1807-12. PubMed PMID: 20564509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of antinociceptive, antinflammatory activities and phytochemical analysis of aerial parts of Urtica urens L. AU - Marrassini,Carla, AU - Acevedo,Cristina, AU - Miño,Jorge, AU - Ferraro,Graciela, AU - Gorzalczany,Susana, PY - 2010/6/22/entrez PY - 2010/6/22/pubmed PY - 2011/2/18/medline SP - 1807 EP - 12 JF - Phytotherapy research : PTR JO - Phytother Res VL - 24 IS - 12 N2 - The antinociceptive and antiinflammatory activities of the ethanol extract of the aerial part of Urtica urens were determined by experimental animal models. U. urens extract was found to possess significant antinociceptive activity in chemically induced mouse pain models (ED₅₀ 39.3 mg/kg: 17.2-74.5 mg/kg) in the writhing test and 62.8% inhibition of the licking time in the late phase of the formalin test at a dose of 500 mg/kg p.o. and antiinflammatory activity on carrageenan-induced rat hind paw edema (41.5% inhibition at a dose of 300 mg/kg i.p.). The extract displayed activity neither in the thermal model of pain nor in the topical inflammation model. The major component of the extract was determined as chlorogenic acid (670 mg/1000 g dry weight) and could be partly responsible for this activity. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/20564509/Evaluation_of_antinociceptive_antinflammatory_activities_and_phytochemical_analysis_of_aerial_parts_of_Urtica_urens_L_ L2 - https://doi.org/10.1002/ptr.3188 DB - PRIME DP - Unbound Medicine ER -