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Milk thistle in liver diseases: past, present, future.
Phytother Res 2010; 24(10):1423-32PR

Abstract

Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70% of silymarin. Silymarin is found in the entire plant but it is concentrated in the fruit and seeds. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation, has antifibrotic activity and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors. In animals, silymarin reduces liver injury caused by acetaminophen, carbon tetrachloride, radiation, iron overload, phenylhydrazine, alcohol, cold ischaemia and Amanita phalloides. Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin-induced liver diseases.

Authors+Show Affiliations

Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy. l.abenavoli@unicz.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20564545

Citation

Abenavoli, Ludovico, et al. "Milk Thistle in Liver Diseases: Past, Present, Future." Phytotherapy Research : PTR, vol. 24, no. 10, 2010, pp. 1423-32.
Abenavoli L, Capasso R, Milic N, et al. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-32.
Abenavoli, L., Capasso, R., Milic, N., & Capasso, F. (2010). Milk thistle in liver diseases: past, present, future. Phytotherapy Research : PTR, 24(10), pp. 1423-32. doi:10.1002/ptr.3207.
Abenavoli L, et al. Milk Thistle in Liver Diseases: Past, Present, Future. Phytother Res. 2010;24(10):1423-32. PubMed PMID: 20564545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk thistle in liver diseases: past, present, future. AU - Abenavoli,Ludovico, AU - Capasso,Raffaele, AU - Milic,Natasa, AU - Capasso,Francesco, PY - 2010/6/22/entrez PY - 2010/6/22/pubmed PY - 2011/1/5/medline SP - 1423 EP - 32 JF - Phytotherapy research : PTR JO - Phytother Res VL - 24 IS - 10 N2 - Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70% of silymarin. Silymarin is found in the entire plant but it is concentrated in the fruit and seeds. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation, has antifibrotic activity and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors. In animals, silymarin reduces liver injury caused by acetaminophen, carbon tetrachloride, radiation, iron overload, phenylhydrazine, alcohol, cold ischaemia and Amanita phalloides. Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin-induced liver diseases. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/20564545/Milk_thistle_in_liver_diseases:_past_present_future_ L2 - https://doi.org/10.1002/ptr.3207 DB - PRIME DP - Unbound Medicine ER -