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[Hypertension in the elderly and risk of dementia].
Rev Prat. 2010 May 20; 60(5):649-53.RP

Abstract

Prevention and treatment of dementia has turned into a major public health challenge. Recent epidemiological studies have shown a significant association between the presence of hypertension and the occurrence of cognitive decline or dementia (including Alzheimer's disease). Indeed, the summation of vascular brain damage and degenerative changes may contribute to an early expression of a still subclinical Alzheimer's disease, causing the threshold of dementia to be reached earlier. Some recent randomized controlled trials (SYST-EUR, PROGRESS, HOPE, SCOPE, HYVET) included cognition as secondary endpoint. Their results open the way for prevention of dementia by antihypertensive treatments. It is therefore necessary that further randomized trials are conducted with the primary objective to assess the impact of antihypertensive treatment on cognitive decline or dementia. In clinical practice, it is important to identify, among hypertensive patients, the subjects at risk for dementia, i.e those who already have mild cognitive impairment or extensive cerebral white matter lesions, in order to optimize blood pressure control and monitor cognitive function (regular cognitive assessment, drugs adherence).

Authors+Show Affiliations

Université Paris Descartes, service de gériatrie, hôpital Broca, AP-HP, 75013, Paris. olivier.hanon@brc.aphp.fr

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

20564847

Citation

Hanon, Olivier. "[Hypertension in the Elderly and Risk of Dementia]." La Revue Du Praticien, vol. 60, no. 5, 2010, pp. 649-53.
Hanon O. [Hypertension in the elderly and risk of dementia]. Rev Prat. 2010;60(5):649-53.
Hanon, O. (2010). [Hypertension in the elderly and risk of dementia]. La Revue Du Praticien, 60(5), 649-53.
Hanon O. [Hypertension in the Elderly and Risk of Dementia]. Rev Prat. 2010 May 20;60(5):649-53. PubMed PMID: 20564847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hypertension in the elderly and risk of dementia]. A1 - Hanon,Olivier, PY - 2010/6/23/entrez PY - 2010/6/23/pubmed PY - 2010/7/23/medline SP - 649 EP - 53 JF - La Revue du praticien JO - Rev Prat VL - 60 IS - 5 N2 - Prevention and treatment of dementia has turned into a major public health challenge. Recent epidemiological studies have shown a significant association between the presence of hypertension and the occurrence of cognitive decline or dementia (including Alzheimer's disease). Indeed, the summation of vascular brain damage and degenerative changes may contribute to an early expression of a still subclinical Alzheimer's disease, causing the threshold of dementia to be reached earlier. Some recent randomized controlled trials (SYST-EUR, PROGRESS, HOPE, SCOPE, HYVET) included cognition as secondary endpoint. Their results open the way for prevention of dementia by antihypertensive treatments. It is therefore necessary that further randomized trials are conducted with the primary objective to assess the impact of antihypertensive treatment on cognitive decline or dementia. In clinical practice, it is important to identify, among hypertensive patients, the subjects at risk for dementia, i.e those who already have mild cognitive impairment or extensive cerebral white matter lesions, in order to optimize blood pressure control and monitor cognitive function (regular cognitive assessment, drugs adherence). SN - 0035-2640 UR - https://www.unboundmedicine.com/medline/citation/20564847/[Hypertension_in_the_elderly_and_risk_of_dementia]_ L2 - https://medlineplus.gov/dementia.html DB - PRIME DP - Unbound Medicine ER -
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