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Investigation and comparison of colon specificity of novel polymer khaya gum with guar gum.
Pak J Pharm Sci. 2010 Jul; 23(3):259-65.PJ

Abstract

To investigate the colon specificity of novel natural polymer khaya gum and compare with guar gum. Release profile of tablets was carried out in presence and absence of rat cecal contents. The fast disintegrating core tablets of budesonide, were initially prepared by direct compression technique. Later, these tablets were coated with khaya gum or guar gum. After suitable pre compression and post compression evaluation, these tablets were further coated using Eudragit L-100 by dip coating technique. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits. The release profiles revealed that khaya gum or guar gum, when used as compression coating, protected the drug from being released in the upper parts of the gastro intestinal tract to some extent but the enteric coated formulations completely protected the drug from being released in the upper parts of the gastro intestinal tract, and released the drug in the colon by bacterial degradation of gums. It was found that both the polysaccharide polymers exhibited different release profiles in presence and absence of rat cecal contents. However, further enteric coat helped in targeting the drug to colon very effectively. Better dissolution models revealed the colon specificity of polysaccharides and alone can not be used either for targeting the drug to the colon or for sustaining or controlling the release of drug.

Authors+Show Affiliations

Prabhu P
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, Karnataka, India. prabhuprashu@rediffmail.com
Ahamed N
No affiliation info available
Matapady HN
No affiliation info available
Ahmed MG
No affiliation info available
Narayanacharyulu R
No affiliation info available
Satyanarayana D
No affiliation info available
Subrahmanayam E
No affiliation info available

MeSH

AnimalsBudesonideColonDrug CarriersGalactansHydrogen-Ion ConcentrationMaleMannansMeliaceaeOrgan SpecificityPlant GumsPolymersRabbitsRatsSolubilityTablets

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20566437

Citation

Prabhu, Prabhakara, et al. "Investigation and Comparison of Colon Specificity of Novel Polymer Khaya Gum With Guar Gum." Pakistan Journal of Pharmaceutical Sciences, vol. 23, no. 3, 2010, pp. 259-65.
Prabhu P, Ahamed N, Matapady HN, et al. Investigation and comparison of colon specificity of novel polymer khaya gum with guar gum. Pak J Pharm Sci. 2010;23(3):259-65.
Prabhu, P., Ahamed, N., Matapady, H. N., Ahmed, M. G., Narayanacharyulu, R., Satyanarayana, D., & Subrahmanayam, E. (2010). Investigation and comparison of colon specificity of novel polymer khaya gum with guar gum. Pakistan Journal of Pharmaceutical Sciences, 23(3), 259-65.
Prabhu P, et al. Investigation and Comparison of Colon Specificity of Novel Polymer Khaya Gum With Guar Gum. Pak J Pharm Sci. 2010;23(3):259-65. PubMed PMID: 20566437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation and comparison of colon specificity of novel polymer khaya gum with guar gum. AU - Prabhu,Prabhakara, AU - Ahamed,Nissara, AU - Matapady,Harish Nairy, AU - Ahmed,Mohd Gulzar, AU - Narayanacharyulu,R, AU - Satyanarayana,D, AU - Subrahmanayam,Evs, PY - 2010/6/23/entrez PY - 2010/6/23/pubmed PY - 2010/8/6/medline SP - 259 EP - 65 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 23 IS - 3 N2 - To investigate the colon specificity of novel natural polymer khaya gum and compare with guar gum. Release profile of tablets was carried out in presence and absence of rat cecal contents. The fast disintegrating core tablets of budesonide, were initially prepared by direct compression technique. Later, these tablets were coated with khaya gum or guar gum. After suitable pre compression and post compression evaluation, these tablets were further coated using Eudragit L-100 by dip coating technique. X-ray images were taken to investigate the movement, location and the integrity of the tablets in different parts of gastro intestinal tract in rabbits. The release profiles revealed that khaya gum or guar gum, when used as compression coating, protected the drug from being released in the upper parts of the gastro intestinal tract to some extent but the enteric coated formulations completely protected the drug from being released in the upper parts of the gastro intestinal tract, and released the drug in the colon by bacterial degradation of gums. It was found that both the polysaccharide polymers exhibited different release profiles in presence and absence of rat cecal contents. However, further enteric coat helped in targeting the drug to colon very effectively. Better dissolution models revealed the colon specificity of polysaccharides and alone can not be used either for targeting the drug to the colon or for sustaining or controlling the release of drug. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/20566437/Investigation_and_comparison_of_colon_specificity_of_novel_polymer_khaya_gum_with_guar_gum_ DB - PRIME DP - Unbound Medicine ER -