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[Is the assessment of biological activity of prolactin essential in the diagnosis of hyperprolactinemia?].
Pol Merkur Lekarski. 2010 May; 28(167):359-61.PM

Abstract

Hyperprolactinemia is one of the most essential reproductive disorders in women and men. The incidence of hyperprolactinemia in women with impaired reproductive function is about 17%. Etiopathogenesis of menstrual disorders in hyperprolactinemia is related to inhibitory influence of prolactin excess on GnRH pulsatile secretion.

THE AIM OF THE STUDY

To evaluate the biological activity of prolactin in hyperprolactinemic patients with regular menstrual cycles and menstrual cycle disorders.

MATERIAL AND METHODS

The study group was composed of 41 women aged between 20-36 years who were hospitalized at the Department of Gynecological Endocrinology, Medical University of Poznah diagnosed with hyperprolactinemia. 23 patients with hyperprolactinemia had regular menstrual cycles. However 18 patients with hyperprolactinemia had menstrual cycle disorders such as: oligomenorrhea or secondary amenorrhea. Control group consisted of 20 healthy women with regular menstrual cycle and normal serum prolactin level. All patients were studied subjective, objective and additional hormonal tests (FSH, LH, PRL, PRL-PEG, E2) in the first menstrual phase, fasting, after a night of rest were perfomed. Prolactin biological activity was estimated by using polyethylene glycol (PEG) method.

RESULTS

Patients with hyperprolactinemia and regular menstrual cycle presented low biological activity of prolactin and normal serum FSH, LH and estradiol levels. Patients with hyperprolactinemia and menstrual cycle disorders presented high biological activity of prolactin. Simultaneously low serum levels of FSH, LH and estradiol were found in this group of patients.

CONCLUSION

The assessment of biological activity of prolactin has an essential aspect in the proper diagnosis of hyperprolactinemia.

Authors+Show Affiliations

Uniwersytet Medyczny w Poznaniu, Katedra i Klinika Endokrynologii Ginekologicznej.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

20568397

Citation

Kostrzak, Anna, et al. "[Is the Assessment of Biological Activity of Prolactin Essential in the Diagnosis of Hyperprolactinemia?]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 28, no. 167, 2010, pp. 359-61.
Kostrzak A, Warenik-Szymankiewicz A, Meczekalski B. [Is the assessment of biological activity of prolactin essential in the diagnosis of hyperprolactinemia?]. Pol Merkur Lekarski. 2010;28(167):359-61.
Kostrzak, A., Warenik-Szymankiewicz, A., & Meczekalski, B. (2010). [Is the assessment of biological activity of prolactin essential in the diagnosis of hyperprolactinemia?]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 28(167), 359-61.
Kostrzak A, Warenik-Szymankiewicz A, Meczekalski B. [Is the Assessment of Biological Activity of Prolactin Essential in the Diagnosis of Hyperprolactinemia?]. Pol Merkur Lekarski. 2010;28(167):359-61. PubMed PMID: 20568397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Is the assessment of biological activity of prolactin essential in the diagnosis of hyperprolactinemia?]. AU - Kostrzak,Anna, AU - Warenik-Szymankiewicz,Alina, AU - Meczekalski,Błazej, PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2010/8/7/medline SP - 359 EP - 61 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol Merkur Lekarski VL - 28 IS - 167 N2 - UNLABELLED: Hyperprolactinemia is one of the most essential reproductive disorders in women and men. The incidence of hyperprolactinemia in women with impaired reproductive function is about 17%. Etiopathogenesis of menstrual disorders in hyperprolactinemia is related to inhibitory influence of prolactin excess on GnRH pulsatile secretion. THE AIM OF THE STUDY: To evaluate the biological activity of prolactin in hyperprolactinemic patients with regular menstrual cycles and menstrual cycle disorders. MATERIAL AND METHODS: The study group was composed of 41 women aged between 20-36 years who were hospitalized at the Department of Gynecological Endocrinology, Medical University of Poznah diagnosed with hyperprolactinemia. 23 patients with hyperprolactinemia had regular menstrual cycles. However 18 patients with hyperprolactinemia had menstrual cycle disorders such as: oligomenorrhea or secondary amenorrhea. Control group consisted of 20 healthy women with regular menstrual cycle and normal serum prolactin level. All patients were studied subjective, objective and additional hormonal tests (FSH, LH, PRL, PRL-PEG, E2) in the first menstrual phase, fasting, after a night of rest were perfomed. Prolactin biological activity was estimated by using polyethylene glycol (PEG) method. RESULTS: Patients with hyperprolactinemia and regular menstrual cycle presented low biological activity of prolactin and normal serum FSH, LH and estradiol levels. Patients with hyperprolactinemia and menstrual cycle disorders presented high biological activity of prolactin. Simultaneously low serum levels of FSH, LH and estradiol were found in this group of patients. CONCLUSION: The assessment of biological activity of prolactin has an essential aspect in the proper diagnosis of hyperprolactinemia. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/20568397/[Is_the_assessment_of_biological_activity_of_prolactin_essential_in_the_diagnosis_of_hyperprolactinemia]_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -
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