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The role of monocytes in atherosclerotic coronary artery disease.
Ann Med. 2010 Sep; 42(6):394-403.AM

Abstract

Inflammation plays a key role in the pathogenesis of atherosclerosis. The more we discover about the molecular pathways involved in atherosclerosis, the more we perceive the importance of monocytes in this process. Circulating monocytes are components of innate immunity, and many pro-inflammatory cytokines and adhesion molecules facilitate their adhesion and migration to the vascular endothelial wall. In addition to the accumulation of lipids and formation of atherogenic 'foam' cells, monocytes may promote atherosclerotic plaque growth by production of inflammatory cytokines, matrix metalloproteinases, and reactive oxidative species. However, the contribution of monocytes to atherogenesis is not only limited to tissue destruction. Monocyte subsets are also involved in intraplaque angiogenesis and tissue reparative processes. The aim of this overview is to discuss the mechanisms of monocyte activation, the pivotal role and importance of activated monocytes in atherosclerotic coronary artery disease, their implication in the development of acute coronary events, and their potential in cardiovascular reparative processes such angiogenesis.

Authors+Show Affiliations

University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, B18 7QH, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20568979

Citation

Pamukcu, Burak, et al. "The Role of Monocytes in Atherosclerotic Coronary Artery Disease." Annals of Medicine, vol. 42, no. 6, 2010, pp. 394-403.
Pamukcu B, Lip GY, Devitt A, et al. The role of monocytes in atherosclerotic coronary artery disease. Ann Med. 2010;42(6):394-403.
Pamukcu, B., Lip, G. Y., Devitt, A., Griffiths, H., & Shantsila, E. (2010). The role of monocytes in atherosclerotic coronary artery disease. Annals of Medicine, 42(6), 394-403. https://doi.org/10.3109/07853890.2010.497767
Pamukcu B, et al. The Role of Monocytes in Atherosclerotic Coronary Artery Disease. Ann Med. 2010;42(6):394-403. PubMed PMID: 20568979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of monocytes in atherosclerotic coronary artery disease. AU - Pamukcu,Burak, AU - Lip,Gregory Y H, AU - Devitt,Andrew, AU - Griffiths,Helen, AU - Shantsila,Eduard, PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2010/11/17/medline SP - 394 EP - 403 JF - Annals of medicine JO - Ann. Med. VL - 42 IS - 6 N2 - Inflammation plays a key role in the pathogenesis of atherosclerosis. The more we discover about the molecular pathways involved in atherosclerosis, the more we perceive the importance of monocytes in this process. Circulating monocytes are components of innate immunity, and many pro-inflammatory cytokines and adhesion molecules facilitate their adhesion and migration to the vascular endothelial wall. In addition to the accumulation of lipids and formation of atherogenic 'foam' cells, monocytes may promote atherosclerotic plaque growth by production of inflammatory cytokines, matrix metalloproteinases, and reactive oxidative species. However, the contribution of monocytes to atherogenesis is not only limited to tissue destruction. Monocyte subsets are also involved in intraplaque angiogenesis and tissue reparative processes. The aim of this overview is to discuss the mechanisms of monocyte activation, the pivotal role and importance of activated monocytes in atherosclerotic coronary artery disease, their implication in the development of acute coronary events, and their potential in cardiovascular reparative processes such angiogenesis. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/20568979/The_role_of_monocytes_in_atherosclerotic_coronary_artery_disease_ L2 - http://www.tandfonline.com/doi/full/10.3109/07853890.2010.497767 DB - PRIME DP - Unbound Medicine ER -