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Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism.
Gynecol Endocrinol. 2010 Oct; 26(10):736-42.GE

Abstract

OBJECTIVE

To investigate glyco-lipidic metabolism and androgenic profile in a cohort of women with polycystic ovary syndrome (PCOS) divided according to Rotterdam phenotypes and body mass index (BMI).

DESIGN

A prospective case-control study.

SETTING

Gynecology department in a teaching hospital. Patients. A total of 223 PCOS women and 25 healthy control women were studied.

METHODS

Patients and controls were subdivided into three groups according to their BMI: normal weight (18.5 ≤ [BMI] ≤24.9 kg/m(2)), overweight (25.0 ≤ BMI ≤29.9 kg/m(2)), or obese (BMI ≥30.0 kg/m(2)) and according to Rotterdam criteria of PCOS. Main outcome measures. Pituitary-gonadal axis assessment including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, PRL, testosterone, androstenedione, DHEA-S, 17-hydroxyprogesterone and inhibin B. Metabolic parameters included cholesterol (Chol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG) and apolipoproteins (APO) AII and B as well as serum fasting insulin, glucose and HOMA-IR.

RESULTS

Serum fasting insulin, glucose, HOMA-IR, TG and HDL were significantly higher in women with PCOS compared to controls. Additionally, serum levels of Chol, LDL and TG were significantly higher and HDL levels were significantly lower in obese PCOS women compared with overweight/normal PCOS irrespective of Rotterdam phenotypes. Free testosterone index but not androstenedione or total testosterone significantly correlated with TG, HDL and APO B. No significant correlations were detected between gonadotropins, inhibin B or estradiol with metabolic parameters studied.

CONCLUSIONS

Obesity but not overweight in PCOS is associated with dyslipidemia. Hyperandrogenic women showed the most atherogenic lipid profiles.

Links

Publisher Full Text

Authors+Show Affiliations

Castelo-Branco C
Faculty of Medicine, Institute Clinic of Gynecology, Obstetrics and Neonatology, University of Barcelona, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS): Barcelona, Spain.
Steinvarcel F
No affiliation info available
Osorio A
No affiliation info available
Ros C
No affiliation info available
Balasch J
No affiliation info available

MeSH

AdultAnovulationAtherosclerosisBody Mass IndexCarbohydrate MetabolismCase-Control StudiesFemaleHumansHyperandrogenismLipid MetabolismMetabolomeObesityPolycystic Ovary SyndromeProspective StudiesRisk FactorsTestosteroneUltrasonographyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20569105

Citation

Castelo-Branco, Camil, et al. "Atherogenic Metabolic Profile in PCOS Patients: Role of Obesity and Hyperandrogenism." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 26, no. 10, 2010, pp. 736-42.
Castelo-Branco C, Steinvarcel F, Osorio A, et al. Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecol Endocrinol. 2010;26(10):736-42.
Castelo-Branco, C., Steinvarcel, F., Osorio, A., Ros, C., & Balasch, J. (2010). Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 26(10), 736-42. https://doi.org/10.3109/09513590.2010.481025
Castelo-Branco C, et al. Atherogenic Metabolic Profile in PCOS Patients: Role of Obesity and Hyperandrogenism. Gynecol Endocrinol. 2010;26(10):736-42. PubMed PMID: 20569105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atherogenic metabolic profile in PCOS patients: role of obesity and hyperandrogenism. AU - Castelo-Branco,Camil, AU - Steinvarcel,Florencia, AU - Osorio,Alois, AU - Ros,Cristina, AU - Balasch,Juan, PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2010/12/16/medline SP - 736 EP - 42 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 26 IS - 10 N2 - OBJECTIVE: To investigate glyco-lipidic metabolism and androgenic profile in a cohort of women with polycystic ovary syndrome (PCOS) divided according to Rotterdam phenotypes and body mass index (BMI). DESIGN: A prospective case-control study. SETTING: Gynecology department in a teaching hospital. Patients. A total of 223 PCOS women and 25 healthy control women were studied. METHODS: Patients and controls were subdivided into three groups according to their BMI: normal weight (18.5 ≤ [BMI] ≤24.9 kg/m(2)), overweight (25.0 ≤ BMI ≤29.9 kg/m(2)), or obese (BMI ≥30.0 kg/m(2)) and according to Rotterdam criteria of PCOS. Main outcome measures. Pituitary-gonadal axis assessment including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, PRL, testosterone, androstenedione, DHEA-S, 17-hydroxyprogesterone and inhibin B. Metabolic parameters included cholesterol (Chol), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG) and apolipoproteins (APO) AII and B as well as serum fasting insulin, glucose and HOMA-IR. RESULTS: Serum fasting insulin, glucose, HOMA-IR, TG and HDL were significantly higher in women with PCOS compared to controls. Additionally, serum levels of Chol, LDL and TG were significantly higher and HDL levels were significantly lower in obese PCOS women compared with overweight/normal PCOS irrespective of Rotterdam phenotypes. Free testosterone index but not androstenedione or total testosterone significantly correlated with TG, HDL and APO B. No significant correlations were detected between gonadotropins, inhibin B or estradiol with metabolic parameters studied. CONCLUSIONS: Obesity but not overweight in PCOS is associated with dyslipidemia. Hyperandrogenic women showed the most atherogenic lipid profiles. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/20569105/Atherogenic_metabolic_profile_in_PCOS_patients:_role_of_obesity_and_hyperandrogenism_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513590.2010.481025 DB - PRIME DP - Unbound Medicine ER -