Tags

Type your tag names separated by a space and hit enter

Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population.
Hum Immunol. 2010 Sep; 71(9):883-7.HI

Abstract

Mannose binding lectin (MBL) is a molecule of the innate immunity, which activates the complement system and modulates inflammation. We investigated the association of the polymorphisms in the exon 1 and promoter region of the MBL gene (MBL2) with the susceptibility to hepatitis C virus (HCV) infection and the degree of liver fibrosis in Brazilian patients chronically infected with HCV. The study was performed in 232 healthy control subjects and 186 patients, 157 of whom underwent liver biopsy after histopathology analysis and classification of fibrosis according to Metavir score. Exon 1 was genotyped by melting temperature assay and the promoter region by Taqman real-time polymerase chain reacation. The frequency of genotypes related to low production of MBL was higher in patients with HCV than in controls (p(c) = 0.0001, odds ratio = 3.52; confidence interval = 1.86-6.71). In addition, the frequency of variant haplotype, HYO was higher in patients with the severe fibrosis stage F4 (10.7%) than in patients with the mild/moderate fibrosis stage F1/F2 (3.4%), when compared with the HYA haplotype (p(c) = 0.04, odds ratio = 5.25, confidence interval = 1.11-23.62). We conclude that MBL variant alleles expressing low levels of MBL are associated with the susceptibility to HCV infection and that the inheritance of HYO haplotype could be associated with fibrosis severity.

Authors+Show Affiliations

Postgraduate Program RENORBIO, Brazil; Institute of Biological Sciences, University of Pernambuco, Recife, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20570631

Citation

Halla, Maria Cristina, et al. "Association of Hepatitis C Virus Infection and Liver Fibrosis Severity With the Variants Alleles of MBL2 Gene in a Brazilian Population." Human Immunology, vol. 71, no. 9, 2010, pp. 883-7.
Halla MC, do Carmo RF, Silva Vasconcelos LR, et al. Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. Hum Immunol. 2010;71(9):883-7.
Halla, M. C., do Carmo, R. F., Silva Vasconcelos, L. R., Pereira, L. B., Moura, P., de Siqueira, E. R., Pereira, L. M., & Mendonça Cavalcanti, M. d. o. . S. (2010). Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. Human Immunology, 71(9), 883-7. https://doi.org/10.1016/j.humimm.2010.05.021
Halla MC, et al. Association of Hepatitis C Virus Infection and Liver Fibrosis Severity With the Variants Alleles of MBL2 Gene in a Brazilian Population. Hum Immunol. 2010;71(9):883-7. PubMed PMID: 20570631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. AU - Halla,Maria Cristina, AU - do Carmo,Rodrigo Feliciano, AU - Silva Vasconcelos,Luydson Richardson, AU - Pereira,Luciano Beltrão, AU - Moura,Patricia, AU - de Siqueira,Erika Rabelo Forte, AU - Pereira,Leila Maria Moreira Beltrão, AU - Mendonça Cavalcanti,Maria do Socorro de, Y1 - 2010/06/01/ PY - 2009/08/17/received PY - 2010/05/18/revised PY - 2010/05/26/accepted PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2011/2/1/medline SP - 883 EP - 7 JF - Human immunology JO - Hum. Immunol. VL - 71 IS - 9 N2 - Mannose binding lectin (MBL) is a molecule of the innate immunity, which activates the complement system and modulates inflammation. We investigated the association of the polymorphisms in the exon 1 and promoter region of the MBL gene (MBL2) with the susceptibility to hepatitis C virus (HCV) infection and the degree of liver fibrosis in Brazilian patients chronically infected with HCV. The study was performed in 232 healthy control subjects and 186 patients, 157 of whom underwent liver biopsy after histopathology analysis and classification of fibrosis according to Metavir score. Exon 1 was genotyped by melting temperature assay and the promoter region by Taqman real-time polymerase chain reacation. The frequency of genotypes related to low production of MBL was higher in patients with HCV than in controls (p(c) = 0.0001, odds ratio = 3.52; confidence interval = 1.86-6.71). In addition, the frequency of variant haplotype, HYO was higher in patients with the severe fibrosis stage F4 (10.7%) than in patients with the mild/moderate fibrosis stage F1/F2 (3.4%), when compared with the HYA haplotype (p(c) = 0.04, odds ratio = 5.25, confidence interval = 1.11-23.62). We conclude that MBL variant alleles expressing low levels of MBL are associated with the susceptibility to HCV infection and that the inheritance of HYO haplotype could be associated with fibrosis severity. SN - 1879-1166 UR - https://www.unboundmedicine.com/medline/citation/20570631/Association_of_hepatitis_C_virus_infection_and_liver_fibrosis_severity_with_the_variants_alleles_of_MBL2_gene_in_a_Brazilian_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(10)00132-1 DB - PRIME DP - Unbound Medicine ER -