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Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status.
Eur J Clin Nutr. 2010 Sep; 64(9):924-32.EJ

Abstract

BACKGROUND

Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent.

OBJECTIVE

We investigated the effects of soy intake on breast cancer risk among Korean women according to their menopausal and hormone receptor status.

METHODS

We conducted a case-control study with 358 incident breast cancer patients and 360 age-matched controls with no history of malignant neoplasm. Dietary consumption of soy products was examined using a 103-item food frequency questionnaire.

RESULTS

The estimated mean intakes of total soy and isoflavones from this study population were 76.5 g per day and 15.0 mg per day, respectively. Using a multivariate logistic regression model, we found a significant inverse association between soy intake and breast cancer risk, with a dose-response relationship (odds ratios (OR) (95% confidence interval (CI)) for the highest vs the lowest intake quartile: 0.36 (0.20-0.64)). When the data were stratified by menopausal status, the protective effect was observed only among postmenopausal women (OR (95% CI) for the highest vs the lowest intake quartile: 0.08 (0.03-0.22)). The association between soy and breast cancer risk did not differ according to estrogen receptor (ER)/progesterone receptor (PR) status, but the estimated intake of soy isoflavones showed an inverse association only among postmenopausal women with ER+/PR+ tumors.

CONCLUSIONS

Our findings suggest that high consumption of soy might be related to lower risk of breast cancer and that the effect of soy intake could vary depending on several factors.

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Authors+Show Affiliations

Cho YA
Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Gyeonggi-do, South Korea.
Kim J
No affiliation info available
Park KS
No affiliation info available
Lim SY
No affiliation info available
Shin A
No affiliation info available
Sung MK
No affiliation info available
Ro J
No affiliation info available

MeSH

AdultAgedBreast NeoplasmsCase-Control StudiesConfidence IntervalsDiet SurveysDose-Response Relationship, DrugFemaleHumansIncidenceIsoflavonesKoreaLogistic ModelsMenopauseMiddle AgedMultivariate AnalysisOdds RatioReceptors, EstrogenReceptors, ProgesteroneRisk FactorsSoy FoodsSurveys and Questionnaires

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20571498

Citation

Cho, Y A., et al. "Effect of Dietary Soy Intake On Breast Cancer Risk According to Menopause and Hormone Receptor Status." European Journal of Clinical Nutrition, vol. 64, no. 9, 2010, pp. 924-32.
Cho YA, Kim J, Park KS, et al. Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. Eur J Clin Nutr. 2010;64(9):924-32.
Cho, Y. A., Kim, J., Park, K. S., Lim, S. Y., Shin, A., Sung, M. K., & Ro, J. (2010). Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. European Journal of Clinical Nutrition, 64(9), 924-32. https://doi.org/10.1038/ejcn.2010.95
Cho YA, et al. Effect of Dietary Soy Intake On Breast Cancer Risk According to Menopause and Hormone Receptor Status. Eur J Clin Nutr. 2010;64(9):924-32. PubMed PMID: 20571498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary soy intake on breast cancer risk according to menopause and hormone receptor status. AU - Cho,Y A, AU - Kim,J, AU - Park,K-S, AU - Lim,S-Y, AU - Shin,A, AU - Sung,M-K, AU - Ro,J, Y1 - 2010/06/23/ PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2010/12/14/medline SP - 924 EP - 32 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 9 N2 - BACKGROUND: Although high soy consumption may be associated with lower breast cancer risk in Asian populations, findings from epidemiological studies have been inconsistent. OBJECTIVE: We investigated the effects of soy intake on breast cancer risk among Korean women according to their menopausal and hormone receptor status. METHODS: We conducted a case-control study with 358 incident breast cancer patients and 360 age-matched controls with no history of malignant neoplasm. Dietary consumption of soy products was examined using a 103-item food frequency questionnaire. RESULTS: The estimated mean intakes of total soy and isoflavones from this study population were 76.5 g per day and 15.0 mg per day, respectively. Using a multivariate logistic regression model, we found a significant inverse association between soy intake and breast cancer risk, with a dose-response relationship (odds ratios (OR) (95% confidence interval (CI)) for the highest vs the lowest intake quartile: 0.36 (0.20-0.64)). When the data were stratified by menopausal status, the protective effect was observed only among postmenopausal women (OR (95% CI) for the highest vs the lowest intake quartile: 0.08 (0.03-0.22)). The association between soy and breast cancer risk did not differ according to estrogen receptor (ER)/progesterone receptor (PR) status, but the estimated intake of soy isoflavones showed an inverse association only among postmenopausal women with ER+/PR+ tumors. CONCLUSIONS: Our findings suggest that high consumption of soy might be related to lower risk of breast cancer and that the effect of soy intake could vary depending on several factors. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20571498/Effect_of_dietary_soy_intake_on_breast_cancer_risk_according_to_menopause_and_hormone_receptor_status_ L2 - https://doi.org/10.1038/ejcn.2010.95 DB - PRIME DP - Unbound Medicine ER -