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Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital.
J Med Virol. 2010 Aug; 82(8):1458-61.JM

Abstract

There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) with the recovery from exacerbations in non-hospitalized asthmatic children (median age 5.1 years) were examined. Human rhinoviruses (HRVs) were present in 52.6% of specimens, HBoV-1 was in 7.7%. Viral co-detections occurred in 25.6% of children and were associated (P = 0.04) with lower asthma quality of life scores upon presentation than were single viral detections. The undifferentiated presence or absence of virus did not influence the severity of asthma or recovery however when virus species were examined individually, specific clinical associations emerged. HRV species C (HRV-Cs) were the viruses most frequently detected as single virus detections. Among 41 genotyped HRVs, more HRV-Cs (n = 23) were identified than HRV-As (n = 16) however HRV-A detection was associated (P = 0.01) with worse asthma symptoms and cough for longer than was HRV-C detection. Larger, PCR-based studies are required to elucidate further the true impact of HRV species in childhood asthma exacerbations of both hospitalized and non-hospitalized cohorts.

Authors+Show Affiliations

Queensland Paediatric Infectious Diseases Laboratory, Sir Albert Sakzewski Virus Research Centre, Queensland Children's Medical Research Institute, Royal Children's Hospital and Clinical Medical Virology Centre, University of Queensland, Brisbane, Queensland, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20572080

Citation

Arden, Katherine E., et al. "Newly Identified Respiratory Viruses in Children With Asthma Exacerbation Not Requiring Admission to Hospital." Journal of Medical Virology, vol. 82, no. 8, 2010, pp. 1458-61.
Arden KE, Chang AB, Lambert SB, et al. Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. J Med Virol. 2010;82(8):1458-61.
Arden, K. E., Chang, A. B., Lambert, S. B., Nissen, M. D., Sloots, T. P., & Mackay, I. M. (2010). Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. Journal of Medical Virology, 82(8), 1458-61. https://doi.org/10.1002/jmv.21819
Arden KE, et al. Newly Identified Respiratory Viruses in Children With Asthma Exacerbation Not Requiring Admission to Hospital. J Med Virol. 2010;82(8):1458-61. PubMed PMID: 20572080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Newly identified respiratory viruses in children with asthma exacerbation not requiring admission to hospital. AU - Arden,Katherine E, AU - Chang,Anne B, AU - Lambert,Stephen B, AU - Nissen,Michael D, AU - Sloots,Theo P, AU - Mackay,Ian M, PY - 2010/6/24/entrez PY - 2010/6/24/pubmed PY - 2010/9/24/medline SP - 1458 EP - 61 JF - Journal of medical virology JO - J Med Virol VL - 82 IS - 8 N2 - There are few data describing the comprehensive identification in and influence of newly identified respiratory viruses on asthma exacerbations. Most studies focus on inpatients. In this preliminary study, the point prevalence and the associations of picornavirus species described recently and human bocavirus (HBoV) with the recovery from exacerbations in non-hospitalized asthmatic children (median age 5.1 years) were examined. Human rhinoviruses (HRVs) were present in 52.6% of specimens, HBoV-1 was in 7.7%. Viral co-detections occurred in 25.6% of children and were associated (P = 0.04) with lower asthma quality of life scores upon presentation than were single viral detections. The undifferentiated presence or absence of virus did not influence the severity of asthma or recovery however when virus species were examined individually, specific clinical associations emerged. HRV species C (HRV-Cs) were the viruses most frequently detected as single virus detections. Among 41 genotyped HRVs, more HRV-Cs (n = 23) were identified than HRV-As (n = 16) however HRV-A detection was associated (P = 0.01) with worse asthma symptoms and cough for longer than was HRV-C detection. Larger, PCR-based studies are required to elucidate further the true impact of HRV species in childhood asthma exacerbations of both hospitalized and non-hospitalized cohorts. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/20572080/Newly_identified_respiratory_viruses_in_children_with_asthma_exacerbation_not_requiring_admission_to_hospital_ L2 - https://doi.org/10.1002/jmv.21819 DB - PRIME DP - Unbound Medicine ER -