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Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects.
Am J Clin Nutr 2010; 92(3):525-31AJ

Abstract

BACKGROUND

The intake of selenium needed for optimal health has not been established. Selenoproteins perform the functions of selenium, and the selenium intake needed for their full expression is not known.

OBJECTIVE

This study sought to determine the intake of selenium required to optimize plasma selenoprotein P (SEPP1) and to compare SEPP1 with other plasma selenium biomarkers.

DESIGN

A 40-wk placebo-controlled, double-blind study of selenium repletion was carried out in 98 healthy Chinese subjects who had a daily dietary selenium intake of 14 micro g. Fourteen subjects each were assigned randomly to daily dose groups of 0, 21, 35, 55, 79, 102, and 125 micro g Se as l-selenomethionine. Plasma glutathione peroxidase (GPX) activity, SEPP1, and selenium were measured. A biomarker was considered to be optimized when its value was not different from the mean value of the subjects receiving larger supplements.

RESULTS

The SEPP1 concentration was optimized at 40 wk by the 35- micro g supplement, which indicated that 49 micro g/d could optimize it. GPX activity was optimized by 21 micro g (total ingestion: 35 micro g/d). The selenium concentration showed no tendency to become optimized.

CONCLUSIONS

The present results indicate that SEPP1 concentration is the best plasma biomarker studied for assessing optimal expression of all selenoproteins, because its optimization required a larger intake of selenium than did GPX activity. On the basis of the selenium intake needed for SEPP1 optimization with adjustments for body weight and individual variation, ap 75 micro g Se/d as selenomethionine is postulated to allow full expression of selenoproteins in US residents. This trial was registered at clinicaltrials.gov as NCT00428649.

Authors+Show Affiliations

Sichuan Provincial Center for Disease Control and Prevention, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20573787

Citation

Xia, Yiming, et al. "Optimization of Selenoprotein P and Other Plasma Selenium Biomarkers for the Assessment of the Selenium Nutritional Requirement: a Placebo-controlled, Double-blind Study of Selenomethionine Supplementation in Selenium-deficient Chinese Subjects." The American Journal of Clinical Nutrition, vol. 92, no. 3, 2010, pp. 525-31.
Xia Y, Hill KE, Li P, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. Am J Clin Nutr. 2010;92(3):525-31.
Xia, Y., Hill, K. E., Li, P., Xu, J., Zhou, D., Motley, A. K., ... Burk, R. F. (2010). Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. The American Journal of Clinical Nutrition, 92(3), pp. 525-31. doi:10.3945/ajcn.2010.29642.
Xia Y, et al. Optimization of Selenoprotein P and Other Plasma Selenium Biomarkers for the Assessment of the Selenium Nutritional Requirement: a Placebo-controlled, Double-blind Study of Selenomethionine Supplementation in Selenium-deficient Chinese Subjects. Am J Clin Nutr. 2010;92(3):525-31. PubMed PMID: 20573787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. AU - Xia,Yiming, AU - Hill,Kristina E, AU - Li,Ping, AU - Xu,Jiayuan, AU - Zhou,Dingyou, AU - Motley,Amy K, AU - Wang,Li, AU - Byrne,Daniel W, AU - Burk,Raymond F, Y1 - 2010/06/23/ PY - 2010/6/25/entrez PY - 2010/6/25/pubmed PY - 2010/9/18/medline SP - 525 EP - 31 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 3 N2 - BACKGROUND: The intake of selenium needed for optimal health has not been established. Selenoproteins perform the functions of selenium, and the selenium intake needed for their full expression is not known. OBJECTIVE: This study sought to determine the intake of selenium required to optimize plasma selenoprotein P (SEPP1) and to compare SEPP1 with other plasma selenium biomarkers. DESIGN: A 40-wk placebo-controlled, double-blind study of selenium repletion was carried out in 98 healthy Chinese subjects who had a daily dietary selenium intake of 14 micro g. Fourteen subjects each were assigned randomly to daily dose groups of 0, 21, 35, 55, 79, 102, and 125 micro g Se as l-selenomethionine. Plasma glutathione peroxidase (GPX) activity, SEPP1, and selenium were measured. A biomarker was considered to be optimized when its value was not different from the mean value of the subjects receiving larger supplements. RESULTS: The SEPP1 concentration was optimized at 40 wk by the 35- micro g supplement, which indicated that 49 micro g/d could optimize it. GPX activity was optimized by 21 micro g (total ingestion: 35 micro g/d). The selenium concentration showed no tendency to become optimized. CONCLUSIONS: The present results indicate that SEPP1 concentration is the best plasma biomarker studied for assessing optimal expression of all selenoproteins, because its optimization required a larger intake of selenium than did GPX activity. On the basis of the selenium intake needed for SEPP1 optimization with adjustments for body weight and individual variation, ap 75 micro g Se/d as selenomethionine is postulated to allow full expression of selenoproteins in US residents. This trial was registered at clinicaltrials.gov as NCT00428649. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20573787/Optimization_of_selenoprotein_P_and_other_plasma_selenium_biomarkers_for_the_assessment_of_the_selenium_nutritional_requirement:_a_placebo_controlled_double_blind_study_of_selenomethionine_supplementation_in_selenium_deficient_Chinese_subjects_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29642 DB - PRIME DP - Unbound Medicine ER -