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Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.
J Nutr Biochem. 2011 Mar; 22(3):227-33.JN

Abstract

Sensory neurons release calcitonin gene-related peptide (CGRP) upon activation. We previously demonstrated that CGRP increases insulin-like growth factor-I (IGF-I) production in various tissues of mice including the skin. We demonstrated that isoflavone increases the CGRP synthesis in the dorsal root ganglion (DRG) neurons in rats. Since IGF-I plays a critical role in hair growth, we hypothesized that isoflavones may promote hair growth by increasing the IGF-I production in hair follicles. We examined this hypothesis using wild-type (WT) and CGRP-knockout (CGRP(-/-)) mice. Isoflavone significantly increased the CGRP mRNA levels in DRG neurons isolated from WT mice (P<.01). Administration of isoflavone for 3 weeks increased the dermal levels of CGRP, IGF-I and IGF-I mRNA in WT mice, but not in CGRP(-/-) mice. Isoflavone administration increased the immunohistochemical expression of IGF-I in hair follicle dermal papilla cells in WT mice. Significant enhancements of hair follicle morphogenesis, hair regrowth, and hair pigmentation were also observed in WT mice administered isoflavone. However, none of these effects in WT mice were observed in CGRP(-/-) mice. These observations strongly suggest that isoflavone might increase IGF-I production in the hair follicle dermal papilla cells in mice through increasing CGRP production in the sensory neurons, thereby promoting hair growth associated with melanogenesis in mice.

Authors+Show Affiliations

Department of Translational Medical Science Research, Nagoya City University, Graduate School of Medical Sciences, Nagoya 467-8601, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20576422

Citation

Zhao, Juan, et al. "Dietary Isoflavone Increases Insulin-like Growth factor-I Production, Thereby Promoting Hair Growth in Mice." The Journal of Nutritional Biochemistry, vol. 22, no. 3, 2011, pp. 227-33.
Zhao J, Harada N, Kurihara H, et al. Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice. J Nutr Biochem. 2011;22(3):227-33.
Zhao, J., Harada, N., Kurihara, H., Nakagata, N., & Okajima, K. (2011). Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice. The Journal of Nutritional Biochemistry, 22(3), 227-33. https://doi.org/10.1016/j.jnutbio.2010.01.008
Zhao J, et al. Dietary Isoflavone Increases Insulin-like Growth factor-I Production, Thereby Promoting Hair Growth in Mice. J Nutr Biochem. 2011;22(3):227-33. PubMed PMID: 20576422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice. AU - Zhao,Juan, AU - Harada,Naoaki, AU - Kurihara,Hiroki, AU - Nakagata,Naomi, AU - Okajima,Kenji, Y1 - 2010/06/23/ PY - 2009/03/25/received PY - 2010/01/26/revised PY - 2010/01/28/accepted PY - 2010/6/26/entrez PY - 2010/6/26/pubmed PY - 2011/6/15/medline SP - 227 EP - 33 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 22 IS - 3 N2 - Sensory neurons release calcitonin gene-related peptide (CGRP) upon activation. We previously demonstrated that CGRP increases insulin-like growth factor-I (IGF-I) production in various tissues of mice including the skin. We demonstrated that isoflavone increases the CGRP synthesis in the dorsal root ganglion (DRG) neurons in rats. Since IGF-I plays a critical role in hair growth, we hypothesized that isoflavones may promote hair growth by increasing the IGF-I production in hair follicles. We examined this hypothesis using wild-type (WT) and CGRP-knockout (CGRP(-/-)) mice. Isoflavone significantly increased the CGRP mRNA levels in DRG neurons isolated from WT mice (P<.01). Administration of isoflavone for 3 weeks increased the dermal levels of CGRP, IGF-I and IGF-I mRNA in WT mice, but not in CGRP(-/-) mice. Isoflavone administration increased the immunohistochemical expression of IGF-I in hair follicle dermal papilla cells in WT mice. Significant enhancements of hair follicle morphogenesis, hair regrowth, and hair pigmentation were also observed in WT mice administered isoflavone. However, none of these effects in WT mice were observed in CGRP(-/-) mice. These observations strongly suggest that isoflavone might increase IGF-I production in the hair follicle dermal papilla cells in mice through increasing CGRP production in the sensory neurons, thereby promoting hair growth associated with melanogenesis in mice. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/20576422/Dietary_isoflavone_increases_insulin_like_growth_factor_I_production_thereby_promoting_hair_growth_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(10)00050-1 DB - PRIME DP - Unbound Medicine ER -