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Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction.
J Gerontol A Biol Sci Med Sci. 2010 Sep; 65(9):915-23.JG

Abstract

To better understand the contribution of the fat mass to the effects of long-term caloric restriction in humans, we compared adipokine profile and insulin sensitivity in long-term calorically restricted formerly obese women (CRW) subjected to different interventions, bariatric surgery, or reducing diet, with age- and BMI-matched obese (OW) and normal-weight women (NW) eating ad libitum. Our key findings are that despite a considerably stronger weight loss induced by bariatric surgery, both long-term caloric restriction interventions improved insulin sensitivity to the same degree and led to significantly lower retinol-binding protein-4 and interleukin-6 serum levels than in OW, suggesting that lowering of these two adipokines contributes to the improved insulin sensitivity. Moreover, serum leptin was considerably lower in CRW than in OW as well as in NW, suggesting that CRW develop hypoleptinemia.

Authors+Show Affiliations

Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20576650

Citation

Mitterberger, Maria C., et al. "Adipokine Profile and Insulin Sensitivity in Formerly Obese Women Subjected to Bariatric Surgery or Diet-induced Long-term Caloric Restriction." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 65, no. 9, 2010, pp. 915-23.
Mitterberger MC, Mattesich M, Klaver E, et al. Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction. J Gerontol A Biol Sci Med Sci. 2010;65(9):915-23.
Mitterberger, M. C., Mattesich, M., Klaver, E., Lechner, S., Engelhardt, T., Larcher, L., Pierer, G., Piza-Katzer, H., & Zwerschke, W. (2010). Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65(9), 915-23. https://doi.org/10.1093/gerona/glq107
Mitterberger MC, et al. Adipokine Profile and Insulin Sensitivity in Formerly Obese Women Subjected to Bariatric Surgery or Diet-induced Long-term Caloric Restriction. J Gerontol A Biol Sci Med Sci. 2010;65(9):915-23. PubMed PMID: 20576650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adipokine profile and insulin sensitivity in formerly obese women subjected to bariatric surgery or diet-induced long-term caloric restriction. AU - Mitterberger,Maria C, AU - Mattesich,Monika, AU - Klaver,Elise, AU - Lechner,Stefan, AU - Engelhardt,Timm, AU - Larcher,Lorenz, AU - Pierer,Gerhard, AU - Piza-Katzer,Hildegunde, AU - Zwerschke,Werner, Y1 - 2010/06/24/ PY - 2010/6/26/entrez PY - 2010/6/26/pubmed PY - 2010/9/16/medline SP - 915 EP - 23 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J Gerontol A Biol Sci Med Sci VL - 65 IS - 9 N2 - To better understand the contribution of the fat mass to the effects of long-term caloric restriction in humans, we compared adipokine profile and insulin sensitivity in long-term calorically restricted formerly obese women (CRW) subjected to different interventions, bariatric surgery, or reducing diet, with age- and BMI-matched obese (OW) and normal-weight women (NW) eating ad libitum. Our key findings are that despite a considerably stronger weight loss induced by bariatric surgery, both long-term caloric restriction interventions improved insulin sensitivity to the same degree and led to significantly lower retinol-binding protein-4 and interleukin-6 serum levels than in OW, suggesting that lowering of these two adipokines contributes to the improved insulin sensitivity. Moreover, serum leptin was considerably lower in CRW than in OW as well as in NW, suggesting that CRW develop hypoleptinemia. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/20576650/Adipokine_profile_and_insulin_sensitivity_in_formerly_obese_women_subjected_to_bariatric_surgery_or_diet_induced_long_term_caloric_restriction_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glq107 DB - PRIME DP - Unbound Medicine ER -