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Melioidosis in southern India: epidemiological and clinical profile.

Abstract

Melioidosis, which is mainly prevalent in Thailand and Australia, has shown an increasing trend in India in the last few years. We carried out a retrospective study of 25 culture-proven adult cases of melioidosis who were admitted to a tertiary care hospital in southern India during June 2001 to September 2007. There was a six-fold increase in the number of cases in 2006 and 2007 as compared to 2001. Diabetes mellitus was the predisposing factor in 68% of cases, followed by alcoholism (28%). The clinical presentations were fever (80%), pneumonia and/or pleural effusion (48%), hepatomegaly (56%), joint involvement, and/or osteomyelitis (48%), splenomegaly (40%), splenic abscess (24%) and septicemia (28%). The organism, Burkholderia pseudomallei, was sensitive to co-amoxiclav, cotrimoxazole, ceftazidime, and carbapenem. The study suggests that melioidosis is an emerging infectious disease in the southwestern coastal belt of India, and it is likely to happen at much higher incidence.

Authors+Show Affiliations

Department of Medicine, Kasturba Medical College, Manipal University, Karnataka, India. kavithasaravu@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20578524

Citation

Saravu, K, et al. "Melioidosis in Southern India: Epidemiological and Clinical Profile." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 41, no. 2, 2010, pp. 401-9.
Saravu K, Mukhopadhyay C, Vishwanath S, et al. Melioidosis in southern India: epidemiological and clinical profile. Southeast Asian J Trop Med Public Health. 2010;41(2):401-9.
Saravu, K., Mukhopadhyay, C., Vishwanath, S., Valsalan, R., Docherla, M., Vandana, K. E., Shastry, B. A., Bairy, I., & Rao, S. P. (2010). Melioidosis in southern India: epidemiological and clinical profile. The Southeast Asian Journal of Tropical Medicine and Public Health, 41(2), 401-9.
Saravu K, et al. Melioidosis in Southern India: Epidemiological and Clinical Profile. Southeast Asian J Trop Med Public Health. 2010;41(2):401-9. PubMed PMID: 20578524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melioidosis in southern India: epidemiological and clinical profile. AU - Saravu,K, AU - Mukhopadhyay,C, AU - Vishwanath,S, AU - Valsalan,R, AU - Docherla,M, AU - Vandana,K E, AU - Shastry,B A, AU - Bairy,I, AU - Rao,S P, PY - 2010/6/29/entrez PY - 2010/6/29/pubmed PY - 2010/10/12/medline SP - 401 EP - 9 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 41 IS - 2 N2 - Melioidosis, which is mainly prevalent in Thailand and Australia, has shown an increasing trend in India in the last few years. We carried out a retrospective study of 25 culture-proven adult cases of melioidosis who were admitted to a tertiary care hospital in southern India during June 2001 to September 2007. There was a six-fold increase in the number of cases in 2006 and 2007 as compared to 2001. Diabetes mellitus was the predisposing factor in 68% of cases, followed by alcoholism (28%). The clinical presentations were fever (80%), pneumonia and/or pleural effusion (48%), hepatomegaly (56%), joint involvement, and/or osteomyelitis (48%), splenomegaly (40%), splenic abscess (24%) and septicemia (28%). The organism, Burkholderia pseudomallei, was sensitive to co-amoxiclav, cotrimoxazole, ceftazidime, and carbapenem. The study suggests that melioidosis is an emerging infectious disease in the southwestern coastal belt of India, and it is likely to happen at much higher incidence. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/20578524/Melioidosis_in_southern_India:_epidemiological_and_clinical_profile_ DB - PRIME DP - Unbound Medicine ER -