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Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility.
J Forensic Sci. 2010 Nov; 55(6):1659-62.JF

Abstract

Pathological gambling (PG), classified in the DSM-IV among impulse control disorders, is defined as inappropriate, persistent gaming for money with serious personal, family, and social consequences. Offenses are frequently committed to obtain money for gambling. Pathological gambling, a planned and structured behavioral disorder, has often been described as a complication of dopamine agonist treatment in patients with Parkinson's disease. It has never been described in patients with schizophrenia receiving dopamine agonists. We present two patients with schizophrenia, previously treated with antipsychotic drugs without any suggestion of PG, who a short time after starting aripiprazole, a dopamine partial agonist, developed PG and criminal behavior, which totally resolved when aripiprazole was discontinued. Based on recent advances in research on PG and adverse drug reactions to dopamine agonists in Parkinson's disease, we postulate a link between aripiprazole and PG in both our patients with schizophrenia and raise the question of criminal responsibility.

Authors+Show Affiliations

Service de Médecine Légale, Faculté de Médecine, Université de la Méditerranée, F-13005 Marseille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20579229

Citation

Gavaudan, Gilles, et al. "Partial Agonist Therapy in Schizophrenia: Relevance to Diminished Criminal Responsibility." Journal of Forensic Sciences, vol. 55, no. 6, 2010, pp. 1659-62.
Gavaudan G, Magalon D, Cohen J, et al. Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility. J Forensic Sci. 2010;55(6):1659-62.
Gavaudan, G., Magalon, D., Cohen, J., Lançon, C., Léonetti, G., & Pélissier-Alicot, A. L. (2010). Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility. Journal of Forensic Sciences, 55(6), 1659-62. https://doi.org/10.1111/j.1556-4029.2010.01483.x
Gavaudan G, et al. Partial Agonist Therapy in Schizophrenia: Relevance to Diminished Criminal Responsibility. J Forensic Sci. 2010;55(6):1659-62. PubMed PMID: 20579229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility. AU - Gavaudan,Gilles, AU - Magalon,David, AU - Cohen,Julien, AU - Lançon,Christophe, AU - Léonetti,Georges, AU - Pélissier-Alicot,Anne-Laure, PY - 2010/6/29/entrez PY - 2010/6/29/pubmed PY - 2011/3/30/medline SP - 1659 EP - 62 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 55 IS - 6 N2 - Pathological gambling (PG), classified in the DSM-IV among impulse control disorders, is defined as inappropriate, persistent gaming for money with serious personal, family, and social consequences. Offenses are frequently committed to obtain money for gambling. Pathological gambling, a planned and structured behavioral disorder, has often been described as a complication of dopamine agonist treatment in patients with Parkinson's disease. It has never been described in patients with schizophrenia receiving dopamine agonists. We present two patients with schizophrenia, previously treated with antipsychotic drugs without any suggestion of PG, who a short time after starting aripiprazole, a dopamine partial agonist, developed PG and criminal behavior, which totally resolved when aripiprazole was discontinued. Based on recent advances in research on PG and adverse drug reactions to dopamine agonists in Parkinson's disease, we postulate a link between aripiprazole and PG in both our patients with schizophrenia and raise the question of criminal responsibility. SN - 1556-4029 UR - https://www.unboundmedicine.com/medline/citation/20579229/Partial_agonist_therapy_in_schizophrenia:_relevance_to_diminished_criminal_responsibility_ L2 - https://doi.org/10.1111/j.1556-4029.2010.01483.x DB - PRIME DP - Unbound Medicine ER -