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Association of serum lycopene and brachial-ankle pulse wave velocity with metabolic syndrome.
Metabolism. 2011 Apr; 60(4):537-43.M

Abstract

Metabolic syndrome (MetS) is known to inversely correlate with antioxidant status. Recently, it has been reported that MetS is associated with arterial stiffness, a composite risk factor for early atherosclerosis. In addition, our recent study for healthy women showed an inverse relationship between arterial stiffness and circulating lycopene. Therefore, this study aimed to investigate the interrelationship between arterial stiffness, antioxidant status, and the risk of MetS. Korean men (N = 299) were subgrouped according to the number of MetS risk factors (RF 0, RF 1-2, RF ≥ 3). Anthropometric parameters, brachial-ankle pulse wave velocity (baPWV; a marker of arterial stiffness), antioxidants (lycopene, β-carotene, α-tocopherol), lipid profiles, glucose, insulin, and oxidative stress (low-density lipoprotein [LDL] particle size, oxidized LDL) were measured. Corresponding to the number of MetS RF, baPWV (1306 ± 17, 1364 ± 16, and 1420 ± 33 cm/s; P < .001) and insulin resistance (1.5 ± 0.1, 1.9 ± 0.1, and 2.7 ± 0.2; P < .001) gradually increased after adjustment for age, body mass index, smoking, and drinking, whereas serum lycopene among antioxidants and LDL particle size gradually decreased (0.036 ± 0.001, 0.031 ± 0.001, and 0.028 ± 0.001 mmol/L; P = .004 and 23.9 ± 0.1, 23.7 ± 0.1, and 23.3 ± 0.1 nm; P < .001, respectively). Brachial-ankle pulse wave velocity inversely correlated with serum lycopene after adjustment for the above confounders, blood pressure, insulin resistance, and oxidative stress (r = -0.136, P < .05). Oxidative stress markers also significantly correlated with baPWV as well as serum lycopene. Study subjects were divided into 2 groups by the median level of serum lycopene. When serum lycopene was lower than median level (≤ 0.0294 mmol/L), baPWV was significantly higher in MetS subjects than non-MetS subjects (1436 ± 41 vs 1367 ± 23 cm/s) after adjustment for age, body mass index, smoking, drinking, and oxidative stress (P = .041). However, when serum lycopene levels were high, no statistically significant difference was observed between the 2 subject groups (1386 ± 36 vs 1326 ± 13 cm/s). In conclusion, our result shows the interrelationship between circulating lycopene, baPWV, and MetS. In addition, much enhanced baPWV in MetS may be associated with lower lycopene concentration.

Authors+Show Affiliations

Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20580031

Citation

Yeo, Hyun Yang, et al. "Association of Serum Lycopene and Brachial-ankle Pulse Wave Velocity With Metabolic Syndrome." Metabolism: Clinical and Experimental, vol. 60, no. 4, 2011, pp. 537-43.
Yeo HY, Kim OY, Lim HH, et al. Association of serum lycopene and brachial-ankle pulse wave velocity with metabolic syndrome. Metabolism. 2011;60(4):537-43.
Yeo, H. Y., Kim, O. Y., Lim, H. H., Kim, J. Y., & Lee, J. H. (2011). Association of serum lycopene and brachial-ankle pulse wave velocity with metabolic syndrome. Metabolism: Clinical and Experimental, 60(4), 537-43. https://doi.org/10.1016/j.metabol.2010.05.003
Yeo HY, et al. Association of Serum Lycopene and Brachial-ankle Pulse Wave Velocity With Metabolic Syndrome. Metabolism. 2011;60(4):537-43. PubMed PMID: 20580031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum lycopene and brachial-ankle pulse wave velocity with metabolic syndrome. AU - Yeo,Hyun Yang, AU - Kim,Oh Yoen, AU - Lim,Hyo Hee, AU - Kim,Ji Young, AU - Lee,Jong Ho, Y1 - 2010/06/26/ PY - 2010/01/19/received PY - 2010/04/18/revised PY - 2010/05/04/accepted PY - 2010/6/29/entrez PY - 2010/6/29/pubmed PY - 2011/5/24/medline SP - 537 EP - 43 JF - Metabolism: clinical and experimental JO - Metabolism VL - 60 IS - 4 N2 - Metabolic syndrome (MetS) is known to inversely correlate with antioxidant status. Recently, it has been reported that MetS is associated with arterial stiffness, a composite risk factor for early atherosclerosis. In addition, our recent study for healthy women showed an inverse relationship between arterial stiffness and circulating lycopene. Therefore, this study aimed to investigate the interrelationship between arterial stiffness, antioxidant status, and the risk of MetS. Korean men (N = 299) were subgrouped according to the number of MetS risk factors (RF 0, RF 1-2, RF ≥ 3). Anthropometric parameters, brachial-ankle pulse wave velocity (baPWV; a marker of arterial stiffness), antioxidants (lycopene, β-carotene, α-tocopherol), lipid profiles, glucose, insulin, and oxidative stress (low-density lipoprotein [LDL] particle size, oxidized LDL) were measured. Corresponding to the number of MetS RF, baPWV (1306 ± 17, 1364 ± 16, and 1420 ± 33 cm/s; P < .001) and insulin resistance (1.5 ± 0.1, 1.9 ± 0.1, and 2.7 ± 0.2; P < .001) gradually increased after adjustment for age, body mass index, smoking, and drinking, whereas serum lycopene among antioxidants and LDL particle size gradually decreased (0.036 ± 0.001, 0.031 ± 0.001, and 0.028 ± 0.001 mmol/L; P = .004 and 23.9 ± 0.1, 23.7 ± 0.1, and 23.3 ± 0.1 nm; P < .001, respectively). Brachial-ankle pulse wave velocity inversely correlated with serum lycopene after adjustment for the above confounders, blood pressure, insulin resistance, and oxidative stress (r = -0.136, P < .05). Oxidative stress markers also significantly correlated with baPWV as well as serum lycopene. Study subjects were divided into 2 groups by the median level of serum lycopene. When serum lycopene was lower than median level (≤ 0.0294 mmol/L), baPWV was significantly higher in MetS subjects than non-MetS subjects (1436 ± 41 vs 1367 ± 23 cm/s) after adjustment for age, body mass index, smoking, drinking, and oxidative stress (P = .041). However, when serum lycopene levels were high, no statistically significant difference was observed between the 2 subject groups (1386 ± 36 vs 1326 ± 13 cm/s). In conclusion, our result shows the interrelationship between circulating lycopene, baPWV, and MetS. In addition, much enhanced baPWV in MetS may be associated with lower lycopene concentration. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20580031/Association_of_serum_lycopene_and_brachial_ankle_pulse_wave_velocity_with_metabolic_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(10)00156-3 DB - PRIME DP - Unbound Medicine ER -