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Body fat changes and activity of tumor necrosis factor α system--a 5-year follow-up study.
Metabolism. 2011 Apr; 60(4):531-6.M

Abstract

Obesity is associated with subclinical, chronic, and systemic immune activation characterized by increased serum concentration of proinflammatory cytokines released by adipose tissue. The aim of the present study was to determine the relationship between stage of development of obesity and changes in activity of tumor necrosis factor (TNF) system during 5-year follow-up observation. One hundred fifty-four women--102 obese, 24 overweight, and 28 lean--without concomitant diseases were examined for the first time from 2000 to 2001. After 5 years, 57 obese, 12 overweight, and 14 lean subjects were reexamined. In addition to anthropometric measurements, body composition was determined by the bioimpedance method; and serum concentrations of glucose, lipids, insulin, TNF-α, and soluble TNF receptors (sTNFRs) were measured. Only reexamined subjects were included in the analysis. After 5 years, fat mass increased significantly in 46 (66.7%) overweight or obese women and in all lean subjects (39.0 ± 12.3 vs 47.3 ± 13.6 kg, P < .001; 14.8 ± 3.7 vs 20.6 ± 5.4 kg, P < .01, respectively), whereas it decreased in 23 (33.3%) overweight or obese subjects (41.3 ± 12.5 vs 37.2 ± 14.0 kg, P < .005). The TNF-α levels increased significantly only in lean women (3.1 ± 3.0 vs 5.6 ± 2.0 pg/mL, P < .005), but remained unchanged in overweight and obese subjects regardless of fat mass changes. Serum concentrations of sTNFR1 and sTNFR2 decreased by 71% and 25% in obese, by 104% and 21% in overweight, and by 31% and 32% in lean group, respectively. The increase of plasma TNF-α level is an early event in abdominal fat accumulation. It seems that further fat mass gain does not enhance circulating TNF-α levels.

Authors+Show Affiliations

Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Katowice 40-752, Poland. magols@esculap.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20580040

Citation

Olszanecka-Glinianowicz, Magdalena, et al. "Body Fat Changes and Activity of Tumor Necrosis Factor Α System--a 5-year Follow-up Study." Metabolism: Clinical and Experimental, vol. 60, no. 4, 2011, pp. 531-6.
Olszanecka-Glinianowicz M, Chudek J, Kocełak P, et al. Body fat changes and activity of tumor necrosis factor α system--a 5-year follow-up study. Metabolism. 2011;60(4):531-6.
Olszanecka-Glinianowicz, M., Chudek, J., Kocełak, P., Szromek, A., & Zahorska-Markiewicz, B. (2011). Body fat changes and activity of tumor necrosis factor α system--a 5-year follow-up study. Metabolism: Clinical and Experimental, 60(4), 531-6. https://doi.org/10.1016/j.metabol.2010.04.023
Olszanecka-Glinianowicz M, et al. Body Fat Changes and Activity of Tumor Necrosis Factor Α System--a 5-year Follow-up Study. Metabolism. 2011;60(4):531-6. PubMed PMID: 20580040.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body fat changes and activity of tumor necrosis factor α system--a 5-year follow-up study. AU - Olszanecka-Glinianowicz,Magdalena, AU - Chudek,Jerzy, AU - Kocełak,Piotr, AU - Szromek,Adam, AU - Zahorska-Markiewicz,Barbara, Y1 - 2010/07/02/ PY - 2010/01/13/received PY - 2010/04/06/revised PY - 2010/04/26/accepted PY - 2010/6/29/entrez PY - 2010/6/29/pubmed PY - 2011/5/24/medline SP - 531 EP - 6 JF - Metabolism: clinical and experimental JO - Metabolism VL - 60 IS - 4 N2 - Obesity is associated with subclinical, chronic, and systemic immune activation characterized by increased serum concentration of proinflammatory cytokines released by adipose tissue. The aim of the present study was to determine the relationship between stage of development of obesity and changes in activity of tumor necrosis factor (TNF) system during 5-year follow-up observation. One hundred fifty-four women--102 obese, 24 overweight, and 28 lean--without concomitant diseases were examined for the first time from 2000 to 2001. After 5 years, 57 obese, 12 overweight, and 14 lean subjects were reexamined. In addition to anthropometric measurements, body composition was determined by the bioimpedance method; and serum concentrations of glucose, lipids, insulin, TNF-α, and soluble TNF receptors (sTNFRs) were measured. Only reexamined subjects were included in the analysis. After 5 years, fat mass increased significantly in 46 (66.7%) overweight or obese women and in all lean subjects (39.0 ± 12.3 vs 47.3 ± 13.6 kg, P < .001; 14.8 ± 3.7 vs 20.6 ± 5.4 kg, P < .01, respectively), whereas it decreased in 23 (33.3%) overweight or obese subjects (41.3 ± 12.5 vs 37.2 ± 14.0 kg, P < .005). The TNF-α levels increased significantly only in lean women (3.1 ± 3.0 vs 5.6 ± 2.0 pg/mL, P < .005), but remained unchanged in overweight and obese subjects regardless of fat mass changes. Serum concentrations of sTNFR1 and sTNFR2 decreased by 71% and 25% in obese, by 104% and 21% in overweight, and by 31% and 32% in lean group, respectively. The increase of plasma TNF-α level is an early event in abdominal fat accumulation. It seems that further fat mass gain does not enhance circulating TNF-α levels. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/20580040/Body_fat_changes_and_activity_of_tumor_necrosis_factor_α_system__a_5_year_follow_up_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(10)00149-6 DB - PRIME DP - Unbound Medicine ER -