TY - JOUR T1 - Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging. AU - Tajiri,Tomokazu, AU - Morita,Shigeaki, AU - Sakamoto,Ryosaku, AU - Suzuki,Masazumi, AU - Yamanashi,Shigeyuki, AU - Ozaki,Yukihiro, AU - Kitamura,Satoshi, Y1 - 2010/05/24/ PY - 2009/11/10/received PY - 2010/04/28/revised PY - 2010/05/18/accepted PY - 2010/6/29/entrez PY - 2010/6/29/pubmed PY - 2010/10/16/medline SP - 147 EP - 53 JF - International journal of pharmaceutics JO - Int J Pharm VL - 395 IS - 1-2 N2 - Release mechanism of acetaminophen (AAP) from extended-release tablets of hydrogel polymer matrices containing polyethylene oxide (PEO) and polyethylene glycol (PEG) were achieved using flow-through cell with magnetic resonance imaging (MRI). The hydrogel forming abilities are observed characteristically and the layer thickness which is corresponding to the diffusion length of AAP has a good correlation with the drug release profiles. In addition, polymeric erosion contribution to AAP releasing from hydrogel matrix tablets was directly quantified using size-exclusion chromatography (SEC). The matrix erosion profile indicates that the PEG erosion kinetic depends primarily on the composition ratio of PEG to PEO. The present study has confirmed that the combination of in situ MRI and SEC should be well suited to investigate the drug release mechanisms of hydrogel matrix such as PEO/PEG. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/20580795/Release_mechanisms_of_acetaminophen_from_polyethylene_oxide/polyethylene_glycol_matrix_tablets_utilizing_magnetic_resonance_imaging_ DB - PRIME DP - Unbound Medicine ER -