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Disinhibition in the unaffected hemisphere is related with the cortical involvement of the affected hemisphere.
Int J Neurosci. 2010 Jul; 120(7):512-5.IJ

Abstract

To investigate whether the disinhibition of the unaffected hemisphere (UH) is related with the lesion location or integrity of the corticospinal tract, we evaluated the intracortical excitability of hand motor cortex in the UH using a paired-pulse transcranial magnetic stimulation paradigm short intracortical inhibition (sICI) and intracortical facilitation (ICF) in 30 subacute stroke survivors. The participants were then classified according to the lesion locations (cortical versus subcortical) and the presence of motor-evoked potential (MEP) response on the paretic hand (MEP+ versus MEP-). The sICI and ICF in the UH were compared according to lesion location and presence of paretic MEP. The sICI and ICF in the UH were comparable between MEP+ and MEP- groups. However, in terms of lesion location, intracortical inhibition was present in patients with subcortical lesions, whereas the patients with cortical lesions showed significant disinhibition in the UH. In conclusion, these findings support that the disinhibition of UH in subacute stage is related to the location of lesion rather than the integrity of the corticospinal tract.

Authors+Show Affiliations

Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-Dong Bundang-Gu, Seongnam, Republic of Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20583905

Citation

Oh, Byung-Mo, et al. "Disinhibition in the Unaffected Hemisphere Is Related With the Cortical Involvement of the Affected Hemisphere." The International Journal of Neuroscience, vol. 120, no. 7, 2010, pp. 512-5.
Oh BM, Kim DY, Paik NJ. Disinhibition in the unaffected hemisphere is related with the cortical involvement of the affected hemisphere. Int J Neurosci. 2010;120(7):512-5.
Oh, B. M., Kim, D. Y., & Paik, N. J. (2010). Disinhibition in the unaffected hemisphere is related with the cortical involvement of the affected hemisphere. The International Journal of Neuroscience, 120(7), 512-5. https://doi.org/10.3109/00207451003760114
Oh BM, Kim DY, Paik NJ. Disinhibition in the Unaffected Hemisphere Is Related With the Cortical Involvement of the Affected Hemisphere. Int J Neurosci. 2010;120(7):512-5. PubMed PMID: 20583905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disinhibition in the unaffected hemisphere is related with the cortical involvement of the affected hemisphere. AU - Oh,Byung-Mo, AU - Kim,Dae-Yul, AU - Paik,Nam-Jong, PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2011/2/4/medline SP - 512 EP - 5 JF - The International journal of neuroscience JO - Int J Neurosci VL - 120 IS - 7 N2 - To investigate whether the disinhibition of the unaffected hemisphere (UH) is related with the lesion location or integrity of the corticospinal tract, we evaluated the intracortical excitability of hand motor cortex in the UH using a paired-pulse transcranial magnetic stimulation paradigm short intracortical inhibition (sICI) and intracortical facilitation (ICF) in 30 subacute stroke survivors. The participants were then classified according to the lesion locations (cortical versus subcortical) and the presence of motor-evoked potential (MEP) response on the paretic hand (MEP+ versus MEP-). The sICI and ICF in the UH were compared according to lesion location and presence of paretic MEP. The sICI and ICF in the UH were comparable between MEP+ and MEP- groups. However, in terms of lesion location, intracortical inhibition was present in patients with subcortical lesions, whereas the patients with cortical lesions showed significant disinhibition in the UH. In conclusion, these findings support that the disinhibition of UH in subacute stage is related to the location of lesion rather than the integrity of the corticospinal tract. SN - 1563-5279 UR - https://www.unboundmedicine.com/medline/citation/20583905/Disinhibition_in_the_unaffected_hemisphere_is_related_with_the_cortical_involvement_of_the_affected_hemisphere_ DB - PRIME DP - Unbound Medicine ER -