Tags

Type your tag names separated by a space and hit enter

Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD).
BMC Gastroenterol. 2010 Jun 28; 10:67.BG

Abstract

BACKGROUND

Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeutic intervention. A novel, simple, and highly accurate scoring system called BARD, which identifies patients with NAFLD and without significant fibrosis, has been recently introduced and validated in North America..The aim of this study is to validate the BARD scoring system in a Polish cohort with NAFLD.

METHODS

A group of 104 Caucasians with biopsy-proven NAFLD were included in this study. Fibrosis in liver biopsies was evaluated according to the Histological Scoring System for Nonalcoholic Fatty Liver Disease. The BARD scoring system was assessed according to Harrison et al.: BMI > or = 28 = 1 point, AST/ALT ratio (AAR) > or = 0.8 = 2 points, type 2 diabetes mellitus = 1 point.

RESULTS

Age over 50 and AAR over 0.8 showed, respectively, a moderate and strong association with advanced fibrosis. A BARD score of 2-4 points was associated with F3 or F4 stages of fibrosis with an odds ratio of 17.333 (95% Cl; 3,639 - 82.558) and negative predictive value of 97%.

CONCLUSION

Our results demonstrate that the BARD scoring system has value in the non-invasive diagnosis of advanced fibrosis in NAFLD patients. The vast majority of patients with NAFLD would avoid liver biopsy if BARD was broadly introduced into the clinic.

Authors+Show Affiliations

Liver Unit, Pomeranian Medical University, Szczecin, Poland. jorasz@sci.pam.szczecin.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

20584330

Citation

Raszeja-Wyszomirska, Joanna, et al. "Validation of the BARD Scoring System in Polish Patients With Nonalcoholic Fatty Liver Disease (NAFLD)." BMC Gastroenterology, vol. 10, 2010, p. 67.
Raszeja-Wyszomirska J, Szymanik B, Ławniczak M, et al. Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD). BMC Gastroenterol. 2010;10:67.
Raszeja-Wyszomirska, J., Szymanik, B., Ławniczak, M., Kajor, M., Chwist, A., Milkiewicz, P., & Hartleb, M. (2010). Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD). BMC Gastroenterology, 10, 67. https://doi.org/10.1186/1471-230X-10-67
Raszeja-Wyszomirska J, et al. Validation of the BARD Scoring System in Polish Patients With Nonalcoholic Fatty Liver Disease (NAFLD). BMC Gastroenterol. 2010 Jun 28;10:67. PubMed PMID: 20584330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD). AU - Raszeja-Wyszomirska,Joanna, AU - Szymanik,Barbara, AU - Ławniczak,Małgorzata, AU - Kajor,Maciej, AU - Chwist,Alina, AU - Milkiewicz,Piotr, AU - Hartleb,Marek, Y1 - 2010/06/28/ PY - 2010/04/20/received PY - 2010/06/28/accepted PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2010/10/12/medline SP - 67 EP - 67 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 10 N2 - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating prognosis and possible therapeutic intervention. A novel, simple, and highly accurate scoring system called BARD, which identifies patients with NAFLD and without significant fibrosis, has been recently introduced and validated in North America..The aim of this study is to validate the BARD scoring system in a Polish cohort with NAFLD. METHODS: A group of 104 Caucasians with biopsy-proven NAFLD were included in this study. Fibrosis in liver biopsies was evaluated according to the Histological Scoring System for Nonalcoholic Fatty Liver Disease. The BARD scoring system was assessed according to Harrison et al.: BMI > or = 28 = 1 point, AST/ALT ratio (AAR) > or = 0.8 = 2 points, type 2 diabetes mellitus = 1 point. RESULTS: Age over 50 and AAR over 0.8 showed, respectively, a moderate and strong association with advanced fibrosis. A BARD score of 2-4 points was associated with F3 or F4 stages of fibrosis with an odds ratio of 17.333 (95% Cl; 3,639 - 82.558) and negative predictive value of 97%. CONCLUSION: Our results demonstrate that the BARD scoring system has value in the non-invasive diagnosis of advanced fibrosis in NAFLD patients. The vast majority of patients with NAFLD would avoid liver biopsy if BARD was broadly introduced into the clinic. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/20584330/Validation_of_the_BARD_scoring_system_in_Polish_patients_with_nonalcoholic_fatty_liver_disease__NAFLD__ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-67 DB - PRIME DP - Unbound Medicine ER -