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Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children.
J Allergy Clin Immunol 2010; 126(2):250-5, 255.e1-4JA

Abstract

BACKGROUND

The rise in asthma prevalence over the last few decades may be a result of changes in prenatal or early-life environment, including maternal diet during pregnancy. Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall dietary pattern.

OBJECTIVE

To determine whether overall maternal dietary pattern during pregnancy is associated with recurrent wheeze in children.

METHODS

A total of 1376 mother-infant pairs from Project Viva, a longitudinal prebirth cohort, who had responses for food frequency questionnaires in the first and second trimester and outcome data at 3 years of age were included. Multivariable logistic regression was used to look at associations between dietary pattern and the primary outcome of recurrent wheeze at 3 years. Overall dietary pattern was examined by using Mediterranean diet score, Alternate Healthy Eating Index modified for pregnancy (AHEI-P), and principal components analysis to look at Western and Prudent diets.

RESULTS

None of these dietary patterns was associated with the primary outcome of recurrent wheeze in children in either the crude or the multivariable model (multivariable model, odds ratio per 1-point increase in Mediterranean diet, 0.98 [95% CI, 0.89-1.08]; AHEI-P, 1.07 [0.87-1.30]; Prudent, 1.02 [0.83-1.26]; Western, 0.98 [0.81-1.19]).

CONCLUSION

Overall dietary pattern during pregnancy is not associated with recurrent wheeze in this cohort. Maternal intake of individual nutrients may be more important determinants of offspring wheeze-associated illness than is dietary pattern.

Authors+Show Affiliations

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. nlange@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20584543

Citation

Lange, Nancy E., et al. "Maternal Dietary Pattern During Pregnancy Is Not Associated With Recurrent Wheeze in Children." The Journal of Allergy and Clinical Immunology, vol. 126, no. 2, 2010, pp. 250-5, 255.e1-4.
Lange NE, Rifas-Shiman SL, Camargo CA, et al. Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children. J Allergy Clin Immunol. 2010;126(2):250-5, 255.e1-4.
Lange, N. E., Rifas-Shiman, S. L., Camargo, C. A., Gold, D. R., Gillman, M. W., & Litonjua, A. A. (2010). Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children. The Journal of Allergy and Clinical Immunology, 126(2), pp. 250-5, 255.e1-4. doi:10.1016/j.jaci.2010.05.009.
Lange NE, et al. Maternal Dietary Pattern During Pregnancy Is Not Associated With Recurrent Wheeze in Children. J Allergy Clin Immunol. 2010;126(2):250-5, 255.e1-4. PubMed PMID: 20584543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in children. AU - Lange,Nancy E, AU - Rifas-Shiman,Sheryl L, AU - Camargo,Carlos A,Jr AU - Gold,Diane R, AU - Gillman,Matthew W, AU - Litonjua,Augusto A, Y1 - 2010/06/26/ PY - 2009/11/24/received PY - 2010/04/30/revised PY - 2010/05/03/accepted PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2010/9/8/medline SP - 250-5, 255.e1-4 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 126 IS - 2 N2 - BACKGROUND: The rise in asthma prevalence over the last few decades may be a result of changes in prenatal or early-life environment, including maternal diet during pregnancy. Previous studies have found associations between individual foods or nutrients consumed during pregnancy and asthma or wheeze in children, but these may be confounded by overall dietary pattern. OBJECTIVE: To determine whether overall maternal dietary pattern during pregnancy is associated with recurrent wheeze in children. METHODS: A total of 1376 mother-infant pairs from Project Viva, a longitudinal prebirth cohort, who had responses for food frequency questionnaires in the first and second trimester and outcome data at 3 years of age were included. Multivariable logistic regression was used to look at associations between dietary pattern and the primary outcome of recurrent wheeze at 3 years. Overall dietary pattern was examined by using Mediterranean diet score, Alternate Healthy Eating Index modified for pregnancy (AHEI-P), and principal components analysis to look at Western and Prudent diets. RESULTS: None of these dietary patterns was associated with the primary outcome of recurrent wheeze in children in either the crude or the multivariable model (multivariable model, odds ratio per 1-point increase in Mediterranean diet, 0.98 [95% CI, 0.89-1.08]; AHEI-P, 1.07 [0.87-1.30]; Prudent, 1.02 [0.83-1.26]; Western, 0.98 [0.81-1.19]). CONCLUSION: Overall dietary pattern during pregnancy is not associated with recurrent wheeze in this cohort. Maternal intake of individual nutrients may be more important determinants of offspring wheeze-associated illness than is dietary pattern. SN - 1097-6825 UR - https://www.unboundmedicine.com/medline/citation/20584543/Maternal_dietary_pattern_during_pregnancy_is_not_associated_with_recurrent_wheeze_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(10)00810-9 DB - PRIME DP - Unbound Medicine ER -