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Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis.
Cytokine. 2010 Sep; 51(3):294-7.C

Abstract

Cerebrospinal fluid (CSF) urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) levels were measured in patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) by quantitative sandwich enzyme immunoassays. The CSF concentrations of uPA and MMP-9 were evaluated in 30 EOMA patients and 10 controls. The CSF uPA and MMP-9 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 73% (22/30) and 86.7% (26/30) for uPA and MMP-9, respectively. The uPA detection was in correlation with headache duration (p=0.008) and stiff neck (p=0.048), while the MMP-9 was in correlation with CSF total protein (p=0.006), CSF leukocytosis (p=0.004) and CSF eosinophil numbers (p=0.02). CSF uPA and MMP-9 levels are potentially useful for the understanding of immunologic pathogenesis, for therapeutic targets, for the diagnosis of EOMA and for monitoring treatment efficacy.

Authors+Show Affiliations

Faculty of Medicine and Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen 40002, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20584616

Citation

Sanpool, Oranuch, et al. "Cerebrospinal Fluid U-plasminogen Activator and Matrix Metalloproteinase-9 Levels in Human Eosinophilic Meningitis Associated With Angiostrongyliasis." Cytokine, vol. 51, no. 3, 2010, pp. 294-7.
Sanpool O, Intapan PM, Thanchomnang T, et al. Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. Cytokine. 2010;51(3):294-7.
Sanpool, O., Intapan, P. M., Thanchomnang, T., Santivarangkana, T., Niwattayakul, K., Chotmongkol, V., & Maleewong, W. (2010). Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. Cytokine, 51(3), 294-7. https://doi.org/10.1016/j.cyto.2010.06.001
Sanpool O, et al. Cerebrospinal Fluid U-plasminogen Activator and Matrix Metalloproteinase-9 Levels in Human Eosinophilic Meningitis Associated With Angiostrongyliasis. Cytokine. 2010;51(3):294-7. PubMed PMID: 20584616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. AU - Sanpool,Oranuch, AU - Intapan,Pewpan M, AU - Thanchomnang,Tongjit, AU - Santivarangkana,Taweesak, AU - Niwattayakul,Kanigar, AU - Chotmongkol,Verajit, AU - Maleewong,Wanchai, Y1 - 2010/06/26/ PY - 2009/12/26/received PY - 2010/05/01/revised PY - 2010/06/02/accepted PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2010/11/11/medline SP - 294 EP - 7 JF - Cytokine JO - Cytokine VL - 51 IS - 3 N2 - Cerebrospinal fluid (CSF) urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) levels were measured in patients with eosinophilic meningitis associated with angiostrongyliasis (EOMA) by quantitative sandwich enzyme immunoassays. The CSF concentrations of uPA and MMP-9 were evaluated in 30 EOMA patients and 10 controls. The CSF uPA and MMP-9 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 73% (22/30) and 86.7% (26/30) for uPA and MMP-9, respectively. The uPA detection was in correlation with headache duration (p=0.008) and stiff neck (p=0.048), while the MMP-9 was in correlation with CSF total protein (p=0.006), CSF leukocytosis (p=0.004) and CSF eosinophil numbers (p=0.02). CSF uPA and MMP-9 levels are potentially useful for the understanding of immunologic pathogenesis, for therapeutic targets, for the diagnosis of EOMA and for monitoring treatment efficacy. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/20584616/Cerebrospinal_fluid_u_plasminogen_activator_and_matrix_metalloproteinase_9_levels_in_human_eosinophilic_meningitis_associated_with_angiostrongyliasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(10)00151-1 DB - PRIME DP - Unbound Medicine ER -