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[Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults].
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jun; 30(6):1247-9.NF

Abstract

OBJECTIVE

To investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA).

METHODS

The patients with phenotypic type 2 diabetes were screened for GAD-Ab positivity, and the 141 positive patients were divided into two subgroups according to the GAD-Ab titer, namely the high-titer group (LADA-1 subtype) and low-titer group (LADA-2 subgroup). The clinical features and insulin resistance were compared between the two groups. Insulin resistance was calculated by HOMA 2 software, and GAD-Ab and C peptide were determined with radioligand and radioimmune assay, respectively.

RESULTS

Compared with low-titer LADA patients, the patients with high titers had younger age of onset, lower BMI, higher HbA1c level, and worse fasting and postprandial C peptide levels. The insulin resistance index by HOMA 2 was significantly lower in LADA-1 group than in LADA-2 group (1.6-/+1.1 vs 2.1-/+1.1, P=0.001). The HOMA2-IR index showed a negative correlation to GAD-Ab titer.

CONCLUSION

The degree of insulin resistance is correlated to GAD-Ab titers in LADA, and low titer patients have higher insulin resistance level.

Authors+Show Affiliations

Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China. hellolxwj@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

20584648

Citation

Li, Xia, et al. "[Relation Between Insulin Resistance and Glutamic Acid Decarboxylase Antibody Titers in Latent Autoimmune Diabetes in Adults]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 30, no. 6, 2010, pp. 1247-9.
Li X, Huang G, Yan X, et al. [Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(6):1247-9.
Li, X., Huang, G., Yan, X., Yang, L., & Zhou, Z. G. (2010). [Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 30(6), 1247-9.
Li X, et al. [Relation Between Insulin Resistance and Glutamic Acid Decarboxylase Antibody Titers in Latent Autoimmune Diabetes in Adults]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(6):1247-9. PubMed PMID: 20584648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]. AU - Li,Xia, AU - Huang,Gan, AU - Yan,Xiang, AU - Yang,Lin, AU - Zhou,Zhi-guang, PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2011/12/13/medline SP - 1247 EP - 9 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 30 IS - 6 N2 - OBJECTIVE: To investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA). METHODS: The patients with phenotypic type 2 diabetes were screened for GAD-Ab positivity, and the 141 positive patients were divided into two subgroups according to the GAD-Ab titer, namely the high-titer group (LADA-1 subtype) and low-titer group (LADA-2 subgroup). The clinical features and insulin resistance were compared between the two groups. Insulin resistance was calculated by HOMA 2 software, and GAD-Ab and C peptide were determined with radioligand and radioimmune assay, respectively. RESULTS: Compared with low-titer LADA patients, the patients with high titers had younger age of onset, lower BMI, higher HbA1c level, and worse fasting and postprandial C peptide levels. The insulin resistance index by HOMA 2 was significantly lower in LADA-1 group than in LADA-2 group (1.6-/+1.1 vs 2.1-/+1.1, P=0.001). The HOMA2-IR index showed a negative correlation to GAD-Ab titer. CONCLUSION: The degree of insulin resistance is correlated to GAD-Ab titers in LADA, and low titer patients have higher insulin resistance level. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/20584648/[Relation_between_insulin_resistance_and_glutamic_acid_decarboxylase_antibody_titers_in_latent_autoimmune_diabetes_in_adults]_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -