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Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome.
Prostate Cancer Prostatic Dis. 2010 Dec; 13(4):338-42.PC

Abstract

The purpose of this study was to assess the diagnostic value and potentially protective capacity of heat-shock protein 70 (HSP70) in chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In this study, seminal plasma levels of cytokines (tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β)) and HSP70 were evaluated by enzyme-linked immunosorbent assay in 80 men: 15 healthy controls, 16 men with chronic bacterial prostatitis, 23 men with CP/CPPS IIIA and 26 with CP/CPPS IIIB. The HSP70 levels in chronic bacterial prostatitis and CP/CPPS patients were correlated with chronic prostatitis symptom index (CPSI). Significantly increased levels of cytokines (TNF-α and IL-1β) and HSP70 were observed in seminal plasmas from patients with chronic bacterial prostatitis compared with CP/CPPS patients and controls. However, only IL-1β was significantly elevated compared with CP/CPPS IIIB and controls in patients with CP/CPPS IIIA. HSP70 levels in CP/CPPS patients were significantly lower than that in controls. HSP70 concentration in seminal plasma was negatively correlated with CPSI in chronic bacterial prostatitis. The results indicated that HSP70 and IL-1β appear to be the most reliable and predictive surrogate markers to diagnose chronic bacterial prostatitis and CP/CPPS, respectively. HSP70 has an important protective role in the regulation of cell functions in chronic bacterial prostatitis. CP/CPPS would probably be detrimental to the ability of T cells and consequently suppress the expression of HSP70.

Authors+Show Affiliations

Department of Urology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20585345

Citation

Guo, H, et al. "Heat-shock Protein 70 Expression in the Seminal Plasma of Patients With Chronic Bacterial Prostatitis and Chronic Prostatitis/chronic Pelvic Pain Syndrome." Prostate Cancer and Prostatic Diseases, vol. 13, no. 4, 2010, pp. 338-42.
Guo H, Xu YM, Ye ZQ, et al. Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome. Prostate Cancer Prostatic Dis. 2010;13(4):338-42.
Guo, H., Xu, Y. M., Ye, Z. Q., Yu, J. H., Fu, Q., Sa, Y. L., Hu, X. Y., & Song, L. J. (2010). Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome. Prostate Cancer and Prostatic Diseases, 13(4), 338-42. https://doi.org/10.1038/pcan.2010.22
Guo H, et al. Heat-shock Protein 70 Expression in the Seminal Plasma of Patients With Chronic Bacterial Prostatitis and Chronic Prostatitis/chronic Pelvic Pain Syndrome. Prostate Cancer Prostatic Dis. 2010;13(4):338-42. PubMed PMID: 20585345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome. AU - Guo,H, AU - Xu,Y-M, AU - Ye,Z-Q, AU - Yu,J-H, AU - Fu,Q, AU - Sa,Y-L, AU - Hu,X-Y, AU - Song,L-J, Y1 - 2010/06/29/ PY - 2010/6/30/entrez PY - 2010/6/30/pubmed PY - 2011/2/25/medline SP - 338 EP - 42 JF - Prostate cancer and prostatic diseases JO - Prostate Cancer Prostatic Dis. VL - 13 IS - 4 N2 - The purpose of this study was to assess the diagnostic value and potentially protective capacity of heat-shock protein 70 (HSP70) in chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In this study, seminal plasma levels of cytokines (tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β)) and HSP70 were evaluated by enzyme-linked immunosorbent assay in 80 men: 15 healthy controls, 16 men with chronic bacterial prostatitis, 23 men with CP/CPPS IIIA and 26 with CP/CPPS IIIB. The HSP70 levels in chronic bacterial prostatitis and CP/CPPS patients were correlated with chronic prostatitis symptom index (CPSI). Significantly increased levels of cytokines (TNF-α and IL-1β) and HSP70 were observed in seminal plasmas from patients with chronic bacterial prostatitis compared with CP/CPPS patients and controls. However, only IL-1β was significantly elevated compared with CP/CPPS IIIB and controls in patients with CP/CPPS IIIA. HSP70 levels in CP/CPPS patients were significantly lower than that in controls. HSP70 concentration in seminal plasma was negatively correlated with CPSI in chronic bacterial prostatitis. The results indicated that HSP70 and IL-1β appear to be the most reliable and predictive surrogate markers to diagnose chronic bacterial prostatitis and CP/CPPS, respectively. HSP70 has an important protective role in the regulation of cell functions in chronic bacterial prostatitis. CP/CPPS would probably be detrimental to the ability of T cells and consequently suppress the expression of HSP70. SN - 1476-5608 UR - https://www.unboundmedicine.com/medline/citation/20585345/Heat_shock_protein_70_expression_in_the_seminal_plasma_of_patients_with_chronic_bacterial_prostatitis_and_chronic_prostatitis/chronic_pelvic_pain_syndrome_ L2 - http://dx.doi.org/10.1038/pcan.2010.22 DB - PRIME DP - Unbound Medicine ER -