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Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium.
Acta Otolaryngol. 2010 Nov; 130(11):1278-86.AO

Abstract

CONCLUSION

It is suggested that TRPV1, 2, 3, and 4, TRPM5 and 8, and TRPA1 may play several roles in the olfactory epithelium (OE), contributing to olfactory chemosensation, olfactory adaptation, olfactory–trigeminal interaction, and OE fluid homeostasis. In patients with olfactory disturbance, TRPV1 and TRPM8 may be closely related to a high rate of recognition of curry and menthol odors, while TRPV2 may also play a crucial role in the regeneration of olfactory receptor neurons.

OBJECTIVE

Expression of TRPV1–4, TRPM5 and 8, and TRPA1 in the normal and methimazole-treated mouse OE was analyzed.

METHODS

The localization of TRPV1–4, TRPM5 and 8, and TRPA1 in the OE of normal and methimazole-treated CBA/J mice was investigated by immunohistochemistry.

RESULTS

Normal OE showed a positive immunofluorescent reaction to TRPV1–4, TRPM5 and 8, and TRPA1. In lamina propria, the nerve fibers displayed TRPV 1, 2, and 3, TRPM8 and TRPA1. In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and took a long time to recover. In contrast, expression of TRPM8 was scarcely affected, even in the pathological condition, while TRPV1 and TRPV2 showed early recovery following methimazole treatment.

Authors+Show Affiliations

Department of Otolaryngology, Hiroshima University, Japan. yosabnm1@hiroshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20586674

Citation

Nakashimo, Yousuke, et al. "Expression of Transient Receptor Potential Channel Vanilloid (TRPV) 1–4, Melastin (TRPM) 5 and 8, and Ankyrin (TRPA1) in the Normal and Methimazole-treated Mouse Olfactory Epithelium." Acta Oto-laryngologica, vol. 130, no. 11, 2010, pp. 1278-86.
Nakashimo Y, Takumida M, Fukuiri T, et al. Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium. Acta Otolaryngol. 2010;130(11):1278-86.
Nakashimo, Y., Takumida, M., Fukuiri, T., Anniko, M., & Hirakawa, K. (2010). Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium. Acta Oto-laryngologica, 130(11), 1278-86. https://doi.org/10.3109/00016489.2010.489573
Nakashimo Y, et al. Expression of Transient Receptor Potential Channel Vanilloid (TRPV) 1–4, Melastin (TRPM) 5 and 8, and Ankyrin (TRPA1) in the Normal and Methimazole-treated Mouse Olfactory Epithelium. Acta Otolaryngol. 2010;130(11):1278-86. PubMed PMID: 20586674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of transient receptor potential channel vanilloid (TRPV) 1–4, melastin (TRPM) 5 and 8, and ankyrin (TRPA1) in the normal and methimazole-treated mouse olfactory epithelium. AU - Nakashimo,Yousuke, AU - Takumida,Masaya, AU - Fukuiri,Takashi, AU - Anniko,Matti, AU - Hirakawa,Katsuhiro, PY - 2010/7/1/entrez PY - 2010/7/1/pubmed PY - 2011/1/29/medline SP - 1278 EP - 86 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 130 IS - 11 N2 - CONCLUSION: It is suggested that TRPV1, 2, 3, and 4, TRPM5 and 8, and TRPA1 may play several roles in the olfactory epithelium (OE), contributing to olfactory chemosensation, olfactory adaptation, olfactory–trigeminal interaction, and OE fluid homeostasis. In patients with olfactory disturbance, TRPV1 and TRPM8 may be closely related to a high rate of recognition of curry and menthol odors, while TRPV2 may also play a crucial role in the regeneration of olfactory receptor neurons. OBJECTIVE: Expression of TRPV1–4, TRPM5 and 8, and TRPA1 in the normal and methimazole-treated mouse OE was analyzed. METHODS: The localization of TRPV1–4, TRPM5 and 8, and TRPA1 in the OE of normal and methimazole-treated CBA/J mice was investigated by immunohistochemistry. RESULTS: Normal OE showed a positive immunofluorescent reaction to TRPV1–4, TRPM5 and 8, and TRPA1. In lamina propria, the nerve fibers displayed TRPV 1, 2, and 3, TRPM8 and TRPA1. In the pathological condition, the expression of TRPV3, TRPV4, TRPM5, and TRPA1 was markedly reduced and took a long time to recover. In contrast, expression of TRPM8 was scarcely affected, even in the pathological condition, while TRPV1 and TRPV2 showed early recovery following methimazole treatment. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/20586674/Expression_of_transient_receptor_potential_channel_vanilloid__TRPV__1–4_melastin__TRPM__5_and_8_and_ankyrin__TRPA1__in_the_normal_and_methimazole_treated_mouse_olfactory_epithelium_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489.2010.489573 DB - PRIME DP - Unbound Medicine ER -