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Antioxidant approaches for the treatment of Alzheimer's disease.
Expert Rev Neurother. 2010 Jul; 10(7):1201-8.ER

Abstract

Oxidative stress is an important factor, and one that acts in the earliest stages, of Alzheimer's disease (AD) pathogenesis. The reduction of oxidative stress has been tested as a therapy for AD. While the trial of vitamin E supplementation in moderately severe AD is the most promising so far, it also reveals the limitations of general antioxidant therapies that simply lower oxidative stress and, therefore, the complexity of the redox system. The multiple contributing factors that foster the clinical manifestations of AD should be considered when designing antioxidative stress therapy. In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches.

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Authors+Show Affiliations

Lee HP
Case Western Reserve University, OH, USA.
Zhu X
No affiliation info available
Casadesus G
No affiliation info available
Castellani RJ
No affiliation info available
Nunomura A
No affiliation info available
Smith MA
No affiliation info available
Lee HG
No affiliation info available
Perry G
No affiliation info available

MeSH

Alzheimer DiseaseAnimalsAntioxidantsClinical Trials as TopicHumansOxidative Stress

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20586698

Citation

Lee, Hyun Pil, et al. "Antioxidant Approaches for the Treatment of Alzheimer's Disease." Expert Review of Neurotherapeutics, vol. 10, no. 7, 2010, pp. 1201-8.
Lee HP, Zhu X, Casadesus G, et al. Antioxidant approaches for the treatment of Alzheimer's disease. Expert Rev Neurother. 2010;10(7):1201-8.
Lee, H. P., Zhu, X., Casadesus, G., Castellani, R. J., Nunomura, A., Smith, M. A., Lee, H. G., & Perry, G. (2010). Antioxidant approaches for the treatment of Alzheimer's disease. Expert Review of Neurotherapeutics, 10(7), 1201-8. https://doi.org/10.1586/ern.10.74
Lee HP, et al. Antioxidant Approaches for the Treatment of Alzheimer's Disease. Expert Rev Neurother. 2010;10(7):1201-8. PubMed PMID: 20586698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant approaches for the treatment of Alzheimer's disease. AU - Lee,Hyun Pil, AU - Zhu,Xiongwei, AU - Casadesus,Gemma, AU - Castellani,Rudy J, AU - Nunomura,Akihiko, AU - Smith,Mark A, AU - Lee,Hyoung-gon, AU - Perry,George, PY - 2010/7/1/entrez PY - 2010/7/1/pubmed PY - 2010/9/30/medline SP - 1201 EP - 8 JF - Expert review of neurotherapeutics JO - Expert Rev Neurother VL - 10 IS - 7 N2 - Oxidative stress is an important factor, and one that acts in the earliest stages, of Alzheimer's disease (AD) pathogenesis. The reduction of oxidative stress has been tested as a therapy for AD. While the trial of vitamin E supplementation in moderately severe AD is the most promising so far, it also reveals the limitations of general antioxidant therapies that simply lower oxidative stress and, therefore, the complexity of the redox system. The multiple contributing factors that foster the clinical manifestations of AD should be considered when designing antioxidative stress therapy. In this article, we discuss the multiple pathogenic mechanisms of oxidative stress in AD and the potential targeting approaches. SN - 1744-8360 UR - https://www.unboundmedicine.com/medline/citation/20586698/Antioxidant_approaches_for_the_treatment_of_Alzheimer's_disease_ L2 - https://www.tandfonline.com/doi/full/10.1586/ern.10.74 DB - PRIME DP - Unbound Medicine ER -