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Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice.
J Helminthol. 2011 Mar; 85(1):92-9.JH

Abstract

Angiostrongylus cantonensis infection causes eosinophilic meningitis in humans. Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. In this study we evaluated the efficacy of the combination of albendazole and baicalein for treating eosinophilic meningitis in BALB/c mice. Therapeutic efficacy included the survival time, body weight, neurological function, leucocyte and eosinophil counts, eotaxin concentration, matrix metalloproteinase-9 (MMP-9) activity, larval recovery and histopathological examination. The results showed that the combination of albendazole and baicalein was more effective than either drug administered singly. Combination therapy increased the survival time, decreased body weight loss, neurological dysfunction, leucocyte response, eotaxin concentration and MMP-9 activity. Our results suggest that the combination of albendazole and baicalein may exhibit synergistic beneficial effects in the treatment of eosinophilic meningitis induced by A. cantonensis.

Authors+Show Affiliations

Department of Parasitology, Zhongshan School of Medicine, SunYat-sen University, 74 Zhongshan 2nd Road, Guangzhou 510080, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20587113

Citation

He, Han-Jiang, et al. "Efficacy of Combined Treatment With Albendazole and Baicalein Against Eosinophilic Meningitis Induced By Angiostrongylus Cantonensis in Mice." Journal of Helminthology, vol. 85, no. 1, 2011, pp. 92-9.
He HJ, Lv ZY, Li ZY, et al. Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. J Helminthol. 2011;85(1):92-9.
He, H. J., Lv, Z. Y., Li, Z. Y., Zhang, L. Y., Liao, Q., Zheng, H. Q., Su, W. Y., Rao, S. Q., Yu, X. B., & Wu, Z. D. (2011). Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. Journal of Helminthology, 85(1), 92-9. https://doi.org/10.1017/S0022149X10000337
He HJ, et al. Efficacy of Combined Treatment With Albendazole and Baicalein Against Eosinophilic Meningitis Induced By Angiostrongylus Cantonensis in Mice. J Helminthol. 2011;85(1):92-9. PubMed PMID: 20587113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. AU - He,Han-Jiang, AU - Lv,Zhi-Yue, AU - Li,Zheng-Yu, AU - Zhang,Li-Yan, AU - Liao,Qi, AU - Zheng,Huan-Qin, AU - Su,Wei-Yang, AU - Rao,Shao-Qi, AU - Yu,Xin-Bing, AU - Wu,Zhong-Dao, Y1 - 2010/06/29/ PY - 2010/7/1/entrez PY - 2010/7/1/pubmed PY - 2011/5/12/medline SP - 92 EP - 9 JF - Journal of helminthology JO - J Helminthol VL - 85 IS - 1 N2 - Angiostrongylus cantonensis infection causes eosinophilic meningitis in humans. Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi. In this study we evaluated the efficacy of the combination of albendazole and baicalein for treating eosinophilic meningitis in BALB/c mice. Therapeutic efficacy included the survival time, body weight, neurological function, leucocyte and eosinophil counts, eotaxin concentration, matrix metalloproteinase-9 (MMP-9) activity, larval recovery and histopathological examination. The results showed that the combination of albendazole and baicalein was more effective than either drug administered singly. Combination therapy increased the survival time, decreased body weight loss, neurological dysfunction, leucocyte response, eotaxin concentration and MMP-9 activity. Our results suggest that the combination of albendazole and baicalein may exhibit synergistic beneficial effects in the treatment of eosinophilic meningitis induced by A. cantonensis. SN - 1475-2697 UR - https://www.unboundmedicine.com/medline/citation/20587113/Efficacy_of_combined_treatment_with_albendazole_and_baicalein_against_eosinophilic_meningitis_induced_by_Angiostrongylus_cantonensis_in_mice_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X10000337/type/journal_article DB - PRIME DP - Unbound Medicine ER -